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The Karthus Senna synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Senna, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Senna. His KDA decreased from NaN to NaN. This drop shows that Senna helps Karthus perform not as well in competitive League games. Yet, the small difference indicates that this performance change is not very impactful.
When Karthus is paired with Senna, he observes a little drop in his complete damage output. This change may demonstrate that Senna does not provide cover for him to deal more damage or that her presence on the team also helps extend the round's duration. Similarly, when Karthus is played alongside Senna on the same side, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Senna.
Moreover, when Karthus plays with Senna on the same side, he typically takes a little less damage than when he plays alone. Taking not as much damage may mean that Senna does a decent job of protecting Karthus during team fights.
There is no one best champion pairing for Karthus that will no matter what be his best teammate. However, overall, Senna is a very typical ally for Karthus. By playing on the same side as Karthus, she decreases their win rate by -0.3% to 47.0%. This shows that there is not really a strong strategic relationship between Karthus and Senna that allows them to perform not as well together than alone.
Senna has a lower difficulty than Karthus. That means Karthus players don't need to be careful when finding Senna allies to go into battle on the same side as, as they will need a relatively low level of skill to play well with you.
Playing on the same side, you should expect to see an overall large increase in your team’s capability to deal magical damage. When paired, these champions can deal quite a lot of AP type damage.
Conversely, by pairing Karthus and Senna together, you probably will not be providing your other teammates very much protection for burst damage. Make sure to pick other champs on your team that fills this hole in this pairing's abilities.
Regardless of your Senna ally's ability, you need to focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you should do well anyway.
If you would like to truly master Karthus to synergize with Senna during both the early game and mid / late game phases of League of Legends rounds, you should keep reading to learn a few extra lessons on this champion pairing. If you use the build and tips displayed here, you will increase your win rate significantly.
The top items to get in your Karthus and Senna synergy build include Cajado do Vazio, Chama Sombria, and Ápice da Tempestade. When Karthus used at least these three great items in his build, he performed significantly better when paired up with Senna than with most other typical item sets. In fact, Karthus had an average win rate of 47.0% helping carry Senna with this build.
To have the greatest probability of crushing your oponents, Karthus players should take the Colheita Sombria, Golpe Desleal, Globos Oculares, Caça Suprema, Presença de Espírito, and Até a Morte runes from the Dominação and Precisão rune sets. Of all the rune combinations that we analyzed for Karthus and Senna pairings, this combination of runes resulted in the greatest win rate. In fact, these runes gave a 47.0% winrate overall.
If you want to see Karthus and Senna synergy tips and builds for a a specific rank, feel free to select one from the selection menu provided above. If viewing for the first time, the statistics and strategies displayed are calculated using all matches completed with these champs.