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The stats provided here emphasize some strategic Karthus versus Seraphine counter statistics that may help you understand the differences between the pair. As an example, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is better than Seraphine’s ratio of NaN, showing that Karthus may be more central to his team's team fighting potential than Seraphine. This observation is in large part fueled by the difference in kills.
Karthus normally has a slightly larger longest killing spree than his opponent does. Typically, he takes more damage than Seraphine. This typically indicates differing health capacities, yet it can also illustrate that the champion with higher health has less mobility and thus is not able to flee from additional damage when poked or engaged.
Both LoL champs are great champions. Both have their pros and cons. In League's current meta, Karthus usually loses when facing off against Seraphine, with a 47.5% win rate. Thus, Karthus makes a bad counter to Seraphine.
While Karthus does have a lower win rate than Seraphine, when on opposite teams, Karthus also has a much greater level of difficulty that makes him a more time consuming champ to pick up and master. You should expect to face a difficult match when picking Karthus into Seraphineas his relative depth means you may not be able to reach his full potential without a significant amount of practice beforehand.
Additionally, Karthus has some amount of CC and other utility, a similar amount to Seraphine. This makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there isn't a single best champion overall in League of Legends, in Karthus vs Seraphine matchups, Seraphine is the better champion with a lower win rate, more champion depth, and a similar amount of utility to help out your allies during late stage team fights.
Karthus is a terribly counter for Seraphine. You will do well by focussing your play on increasing your gold income and clearing objectives. If you can do that, you should do very well as Karthus against Seraphine.
If you would like to learn all of the intricacies of Karthus in order to counter Seraphine during both the lane and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you mind the build and tips presented above, you should increase your win rate by a lot and be closer to League of Legends pro players.
Karthus most often picks up a similar amount of CS relative to Seraphine. Champions who typically don't acquire much CS typically don't require much CS to be valuable teammates, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually need many items to be effective. In either case, try to exceed the numbers shown here to do well.
The top items to use in your Karthus versus Seraphine build include Capuz da Morte de Rabadon, Malevolência, and Tormento de Liandry. When Karthus included at least these three items in his build, he performed a lot better vs Seraphine than with most other commonly used item sets. In fact, Karthus had an average win rate of 47.5% battling Seraphine with this counter build.
To have the best likelihood of annihilating Seraphine as Karthus, you should use the Colheita Sombria, Golpe Desleal, Globos Oculares, Caça Suprema, Presença de Espírito, and Até a Morte runes from the Dominação and Precisão rune sets. Of all the rune builds that we analyzed for Karthus vs Seraphine face-offs, this blending of runes resulted in the highest win rate. Moreover, these runes gave a 47.5% win rate overall.
By default, tips, stats, and builds on how to beat Seraphine as Karthus are shown for every ranked division. If you want to filter the statistics and builds to an individual division, you should use the selection menu located earlier on the page.