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The Senna Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA decreased from NaN to NaN. This fall shows that Kai'Sa helps Senna perform not as well in ranked League games. Yet, the small difference proves that this performance change is only marginal.
When Senna is paired with Kai'Sa, she observes a little drop in her full damage output. This difference could demonstrate that Kai'Sa does not help protection for her to dish out more damage or that her participation also helps extend the round's duration. Similarly, when Senna is played with Kai'Sa on the same side, he usually scores many fewer killing sprees than when she plays without Kai'Sa. This is contrasting evidence that she is worse when playing with Kai'Sa.
Moreover, when Senna plays with Kai'Sa on the same team, she on average receives a little more damage than when she fights alone. Taking more damage may indicate that Kai'Sa does a poor job of protecting Senna in team fights.
There is no one best companion for Senna that will 100% of the time be her best ally. Yet, Kai'Sa is a terrible teammate for Senna. By playing on the same side as Senna, she lowers their win rate by -5.9% to 44.9%. This proves that there is a terrible bond between Senna and Kai'Sa that results in them performing not as well together than without each other.
Kai'Sa has a lower difficulty than Senna. That means Senna players don't need to be cautious when arranging Kai'Sa comrades to go into battle on the same side as, as they will have to have a relatively low level of skill to work well with you.
Working together, Senna players will likely observe an overall large increase in your team’s ability to dish out massive AD. When paired, these two can tear through the other team with a lot of physcial damage.
In contrast, by bringing Senna and Kai'Sa together, you will not be granting your other allies much engage. We recommend you include other champs on your team that helps cover this gap in their capabilities.
Regardless of the skill of your Kai'Sa teammate, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well anyway.
To truly master Senna in order to work well with Kai'Sa during both the early game and mid / late game phases of League of Legends matches, you should continue reading to pick up some more tricks and insights into this champion pairing. If you listen to the build and stats presented above, you should grow your win rate by a lot.
The best items to use in your Senna and Kai'Sa synergy build consist of Lama di Youmuu, Fine della notte, and Canto di sangue. When Senna used at least these three pieces in her build, she performed a lot better when fighting alongside Kai'Sa than with many other typical item sets. In fact, Senna had an average winrate of 44.9% when playing alongside Kai'Sa with these items in her kit.
To have the greatest probability of annihilating your oponents, you should take the Piede lesto, Presenza di spirito, Leggenda: Alacrità, Taglio profondo, Velocità di avvicinamento, and Consegna biscotti runes from the Precisione and Ispirazione rune sets. Of all the rune builds players picked for this team composition, this blending of runes resulted in the highest win rate. In fact, these runes averaged a 44.9% winrate overall.
By default, tips, stats, and builds on how to synergize Kai'Sa with Senna are given for all ranked divisions. To scope the stats and builds to an individual division, you can use the selection menu located earlier in the counter matchup guide.