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The stats provided here emphasize some critical Vayne against Zeri matchup statistics that can help us appreciate the distinctions between the two. Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is better than Zeri’s KDA ratio of NaN, indicating that Vayne may be more central to her team's team fighting effectiveness than Zeri..
Vayne typically has a similar longest kill spree as her enemy does. Typically, she receives a similar amount of damage to Zeri. This typically indicates different amounts of tankyness, but it can also imply that the one champion has less mobility and thus is unable to flee from additional harm when engaged or poked.
Both LoL champions are great. Both have their strengths, weaknesses, and counters. In the game's current meta, Vayne usually wins when playing against Zeri, with a 54.8% win rate. As a result, Vayne makes a great counter to Zeri.
While Vayne does have a much higher win rate compared to Zeri, when facing one another, Vayne also has a greater level of difficulty that makes her a more time consuming champ to pick up and master. You should be be fine when picking Vayne into Zerias her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Furthermore, Vayne also has some amount of utility and CC, a similar amount to Zeri. This makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there isn't a single best champion for every situation in League of Legends, in Vayne vs Zeri matchups, Vayne is the better champ with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your team members during team fights.
Vayne is a great counter to Zeri. Focus your gameplay on maximizing your gold income and taking out objectives. If you can do that, you should do very well as Vayne against Zeri.
To truly master Vayne in order to counter Zeri during both the early game and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you pay attention to the build and stats presented here, you should increase your win rate by a lot and be closer to League of Legends pro players.
Vayne most often gets a similar amount of CS as Zeri. Champs who typically don't take many minion kills often don't require much CS to be effective, such as supports. They are able to scale well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually need many items to be effective. In either case, try to surpass the numbers reported on this page to do well.
The most important items to prioritize in your Vayne versus Zeri build include Lama del re in rovina, Terminus, and Uccisore di Kraken. When Vayne used at least these three items in her build, she did much better countering Zeri than with most other common item sets. In fact, Vayne had an average winrate of 54.8% battling Zeri with this counter build.
To have the highest chance of defeating Zeri as Vayne, Vayne players should equip the Tempo letale, Trionfo, Leggenda: Alacrità, Colpo di grazia, Preparazione fisica, and Crescita eccessiva runes from the Precisione and Determinazione rune sets. Out of all the rune sets players chose for Vayne vs Zeri battles, this combo of runes yielded the highest win rate. Moreover, these runes provided a 54.8% winrate overall.
If you need to get Vayne x Zeri tips and counter builds for a a particular skill level, please choose one from the selection menu above. At first, the stats and build suggestions displayed are computed using every match played with these champions.