League of Legends Karma players will find her to be a challenging champ to build out properly. You will see that her build varies when she is up against either generic or specialized team compositions, meaning you should not choose the same Karma build every single round of League of Legends
The most important items to include in your champion's build are: Echi di Helia, Mandato imperiale, and Staffa delle correnti. Players who included these pieces in their kits had a much higher win rate than players who went for other Karma builds. Moreover, if you are fighting a well-mixed enemy team comp, you should really consider grabbing yourself the Stregoneria, and Determinazione runes. In recent matches, she won the largest number of her rounds when using these runes.
We set our Karma build recommendations by examining 69.811 recently ranked League of Legends games with her in them. We only propose the best winrate Karma builds that have been built by ranked players enough times for us to advise them. With so many matches in our data, we are confident in our recommended builds.