LoL Kai'Sa players will likely find her to be a complex character to build out properly. You'll notice that her build varies when she is playing against either diversified or specialized team comps, indicating you should not follow the same Kai'Sa build every game of League of Legends
The most critical items to incorporate into your champion's build include: Lame rapide Navori, Danzatore fantasma, and Il Collezionista. Those who added these items in their gear had a higher winrate than players who worked towards other item builds for Kai'Sa. Similarly, if you are fighting a well-mixed enemy team arrangement, you should strongly consider getting Kai'Sa the Dominazione, and Precisione runes. In recent matches, she won the greatest percentage of her matches when using these runes.
We set our Kai'Sa build guidance by analyzing 325.819 recently ranked League matches with her in them. We only recommend the best winrate Kai'Sa builds that were used by ranked gamers enough times for us to suggest them. With so many rounds in our data, we are quite confident in our recommended builds.