League of Legends Vayne players will find her to be a dynamic character to build out properly. You'll see that her build changes when she is playing against either well-rounded or specialized team comps, indicating you shouldn't choose the same Vayne build every single game of League of Legends
The most essential items to include in your champion's build include: Force de la trinité, Au bout du rouleau, and Gueule de Malmortius. Players who included these items in their setups had a significantly better win rate than players who utilized other builds for Vayne. Moreover, if you are fighting a well-mixed enemy team composition, you should strongly consider getting Vayne the Précision, and Volonté runes. In recent games, she won the largest percentage of her games when built with these runes.
We established our Vayne build recommendations by analyzing 199 401 recently ranked League of Legends games with her in them. We only propose the top winrate Vayne builds that were built by ranked LoL players enough times for us to propose them. With so many games in our dataset, we are quite confident in our suggested builds.