LoL Senna players will find her to be a challenging character to build out properly. You will notice that her build changes when she is playing against either diversified or highly focused team compositions, meaning you should not select the same Senna build every single game of League of Legends
The best items to include in your champ's build are: Éclipse, Glaive d'ombre, and Arc axiomatique. Those who included these pieces in their setups had a much better win rate than those who went for other item builds for Senna. Similarly, if you are fighting a mixed enemy team composition, you should really consider grabbing Senna the Précision, and Sorcellerie runes. In recent games, she won the greatest fraction of her games when built with these runes.
We calculated our Senna build guidance by analyzing 192 916 recently ranked LoL rounds with her selected. We only advise the top winrate Senna builds that were used by ranked LoL players enough times for us to advise them. With so many matches in our data, we are quite confident in our provided builds.