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The Senna Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This negative change shows that Karthus helps Senna perform worse in competitive League of Legends rounds. Yet, the small difference shows that this performance change is only marginal.
When Senna is an ally to Karthus, she gets a little drop in her full damage dealt. This change could demonstrate that Karthus does not help protection for her to deal more damage or that his presence on the team also helps extend the game's duration. Similarly, when Senna is played together with Karthus on the same side, he usually scores many fewer killing sprees than when she plays without Karthus. This is contrasting evidence that she is worse when playing alongside Karthus.
Additionally, when Senna plays with Karthus on the same team, she typically takes more damage than when she plays alone. Receiving more damage may mean that Karthus does a poor job of covering Senna during team fights.
There is no one best companion for Senna that will 100% of the time be her top teammate. Yet, overall, Karthus is a terrible companion for Senna. By playing on the same side as Senna, he drops their win rate by -3.8% to 47.0%. This clearly indicates that there is a terrible strategic relationship between Senna and Karthus that allows them to perform not as well together than alone.
Karthus has a lower difficulty than Senna. That means Senna players don't need to be very careful when finding Karthus teammates to play with, as they will require a lower level of skill to work well with you.
Playing alongside, Senna players should see an overall large increase in your team’s ability to to do a lot of AP damage. When paired, these two are able to dish out a surprising amount of magic type damage.
Conversely, by bringing Senna and Karthus together, you will not be providing your other teammates much engage. Plan to include other champs on your team that fills this relative disparity in this pairing's capabilities.
Regardless of your Karthus ally's skill level, you need to focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well, regardless.
If you would like to truly master Senna to synergize with Karthus during both the lane and mid / late game phases of League rounds, you should continue reading to learn a few extra lessons on this champion pairing. If you listen to the build and stats presented above, you will grow your win rate significantly.
The ideal items to have in your Senna and Karthus synergy build consist of Lord Dominiks Grüße, Blutgesang, and Der Sammler. When Senna used at least these three great items in her build, she did much better as an ally of Karthus than with many other common item sets. In fact, Senna had an average winrate of 47.0% helping carry Karthus with this build.
To have the best probability of coming out on top against your oponents, Senna players should take the Leichtfüßigkeit, Geistesgegenwart, Legende: Eifer, Niedermäher, Knochenpanzerung, and Frische runes from the Präzision and Entschlossenheit rune sets. Out of all the rune builds players picked for this team composition, this mixture of runes yielded the greatest win rate. In fact, these runes provided a 47.0% winrate overall.
By default, tips, statistics, and builds on how to pair Karthus with Senna are given for all ranked divisions combined. To narrow the stats and builds to a particular division, you may use the selection menu earlier in the counter matchup guide.