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The Karthus Sett synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Sett, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Sett. His KDA worsened from NaN to NaN. This drop shows that Sett helps Karthus perform worse in competitive LoL rounds. Yet, the small difference shows that this performance change is only marginal.
When Karthus is an ally to Sett, he gets a small increase in his complete damage dealt. This could demonstrate that Sett helps provide cover for him to deal more damage or that his participation also helps increase the game's duration. Similarly, when Karthus is played with Sett on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Sett.
Additionally, when Karthus plays with Sett on the same team, he usually receives a little more damage than when he fights alone. Taking more damage could mean that Sett does a poor job of covering Karthus during team fights.
There is no universally accepted best synergy for Karthus that will always be his #1 teammate. Yet, Sett is a decent companion for Karthus. By locking into the same team as Karthus, he improves their win rate by 2.0% to 49.3%. This signals that there is a somewhat important synergy between Karthus and Sett that allows them to perform stronger together than without each other.
Sett has a much lower diffuclty than Karthus. That means Karthus players don't need to be careful when finding Sett comrades to play with, as they will need a much lower level of skill to work well with you.
Working together, you will likely witness an overall large increase in your team’s capacity to to do a lot of AP damage. Together, these champs can deal quite a lot of AP type damage.
In contrast, by grouping Karthus and Sett together, you will not be giving your other allies much support. We recommend you have other champs on your team that nullifies this relative disparity in this pairing's capabilities.
Regardless of your Sett ally's skill level, you should focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
If you would like to learn all of the intricacies of Karthus to synergize with Sett during both the early game and mid / late game phases of LoL, you should keep reading to pick up some more tricks and insights into this champion pairing. If you pay attention to the build and suggestions presented here, you should grow your win rate significantly.
The best finished items to have in your Karthus and Sett synergy build include Rabadons Todeshaube, Schattenflamme, and Sturmblitz. When Karthus incorporated at least these three pieces in his build, he did a lot better when paired up with Sett than with most other common item sets. In fact, Karthus had an average win rate of 49.3% when playing alongside Sett with this build.
To have the greatest chance of vanquishing your oponents, you should use the Dunkle Seelenernte, Perfider Trick, Argus' Vermächtnis, Schatzjäger, Gnadenstoß, and Geistesgegenwart runes from the Dominanz and Präzision rune sets. Out of all the runes players chose for Karthus and Sett pairings, this mix of runes resulted in the greatest win rate. Moreover, these runes provided a 49.3% winrate overall.
By default, tips, stats, and builds on how to team up Sett with Karthus are shown for all skill levels combined. To narrow the stats and builds to a distinct player tier, you may use the selection menu above.