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The Karthus Senna synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Senna, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Senna. His KDA went down from NaN to NaN. This decrease shows that Senna helps Karthus perform poorer in competitive League matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Karthus is an ally to Senna, he observes a small decrease in his full damage output. This may signal that Senna does not help protection for him to dish out more damage or that her support also helps increase the game's duration. Similarly, when Karthus is played with Senna on the same side, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing alongside Senna.
Additionally, when Karthus plays with Senna on the same side, he usually receives a little less damage than when he fights alone. Receiving not as much damage may indicate that Senna does a decent job of protecting Karthus during teamfights.
There is no universally accepted best champion pairing for Karthus that will no matter what be his best synergy. However, Senna is a very typical companion for Karthus. By playing on the same team as Karthus, she decreases their win rate by -0.3% to 47.0%. This signals that there is a weak synergy between Karthus and Senna that results in them performing worse together than alone.
Senna has a lower difficulty than Karthus. That means you don't need to be very careful when arranging Senna teammates to go into battle on the same side as, as they will need a lower level of skill to cooperate well with you.
Playing on the same side, Karthus players should expect to observe an overall large increase in your team’s ability to to do a lot of AP damage. Together, these champs can blast through enemies with magic damage.
Although, by grouping Karthus and Senna together, you will not be giving your team a lot of engage. We recommend you pick other champs on your team that offsets this relative hole in this pairing's capabilities.
Regardless of your Senna ally's skill level, you should focus on increasing your gold income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you will do well anyway.
If you would like to truly master Karthus to synergize with Senna during both the early game and mid / late game phases of League of Legends matches, you should continue reading to pick up a few extra lessons on this champion pairing. If you listen to the build and suggestions shown here, you will grow your win rate significantly.
The ideal finished items to focus on in your Karthus and Senna synergy build consist of Leerenstab, Schattenflamme, and Sturmblitz. When Karthus used at least these three finished items in his build, he performed much better when paired up with Senna than with many other typical builds. In fact, Karthus had an average winrate of 47.0% helping carry Senna with this build.
To have the best probability of beating your oponents, you should use the Dunkle Seelenernte, Perfider Trick, Argus' Vermächtnis, Ultimativer Jäger, Geistesgegenwart, and Letztes Gefecht runes from the Dominanz and Präzision rune sets. Of all the runes that we analyzed for this champion pairing, this mix of runes yielded the best win rate. In fact, these runes averaged a 47.0% winrate overall.
By default, tips, statistics, and builds on how to synergize Senna with Karthus are presented for all skill levels combined. To scope the stats and builds to a particular division, you may use the selection menu located earlier in the counter matchup guide.