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The Karthus K'Sante synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with K'Sante, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with K'Sante. His KDA fell from NaN to NaN. This worsening shows that K'Sante helps Karthus perform worse in ranked League matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus is an ally to K'Sante, he gets a small increase in his total damage dealt. This difference may indicate that K'Sante provides protection for him to deal more damage or that their allyship also helps increase the match's duration. Similarly, when Karthus is played with K'Sante on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing alongside K'Sante.
Moreover, when Karthus plays with K'Sante on the same team, he often receives a little more damage than when he fights alone. Receiving more damage could indicate that K'Sante does a poor job of protecting Karthus in teamfights.
There is no top synergy for Karthus that will 100% of the time be his #1 synergy. However, overall, K'Sante is a relatively poor ally for Karthus. By being on the same team as Karthus, they decreases their win rate by -3.0% to 44.3%. This shows that there is a negative bond between Karthus and K'Sante that allows them to perform worse together than without each other.
K'Sante has a greater difficulty than Karthus. That means you must be careful when arranging K'Sante comrades to play with, as they will require a greater level of skill to play well with you.
When playing together, Karthus players will likely observe an overall large increase in your team’s capacity to deal magic damage. Together, these two can deal quite a lot of AP type damage.
Conversely, by bringing Karthus and K'Sante together, you may not be giving your other allies much support. We recommend you include other champions on your team that offsets this relative gap in this pairing's playstyle.
Regardless of the ability of your K'Sante ally, you need to focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well, regardless.
To truly master Karthus in order to work well with K'Sante during both the laning and mid / late game phases of League of Legends games, you should keep reading to master some more lessons on this champion pairing. If you listen to the build and stats presented here, you should grow your win rate significantly.
The most crucial finished items to prioritize in your Karthus and K'Sante synergy build consist of Rabadons Todeshaube, Schattenflamme, and Liandrys Qual. When Karthus incorporated at least these three finished items in his build, he performed significantly better when fighting alongside K'Sante than with many other common builds. In fact, Karthus boasted an average win rate of 44.3% when playing alongside K'Sante with these items in his kit.
To have the best probability of defeating your oponents, you should equip the Erstschlag, Magisches Schuhwerk, Zukunftsmarkt, Kosmische Einsicht, Argus' Vermächtnis, and Ultimativer Jäger runes from the Inspiration and Dominanz rune sets. Of all the rune builds players used for this team composition, this composite of runes resulted in the best win rate. Moreover, these runes averaged a 44.3% winrate overall.
By default, tips, statistics, and builds on how to pair K'Sante with Karthus are shown for all skill levels combined. To filter the statistics and builds to a specific skill level, you should use the selection menu located earlier in the counter matchup guide.