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The Cassiopeia Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Cassiopeia sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This negative change shows that Karthus helps Cassiopeia perform not as well in competitive LoL games. Yet, the small difference proves that this performance change is only marginal.
When Cassiopeia is paired with Karthus, she gets a barely noticable drop in her full damage dealt. This change may demonstrate that Karthus doesn't help cover for her to deal more damage or that his allyship also helps extend the game's duration. Similarly, when Cassiopeia is played with Karthus on the same side, he usually scores many fewer killing sprees compared to when she plays without Karthus. This is contrasting evidence that she is worse when playing with Karthus.
Moreover, when Cassiopeia plays with Karthus on the same side, she often takes more damage than when she plays alone. Receiving more damage could mean that Karthus does a poor job of covering Cassiopeia in team fights.
There is no universally accepted best champion pairing for Cassiopeia that will no matter what be her ideal synergy. However, Karthus is a terrible companion for Cassiopeia. By being on the same team as Cassiopeia, he lowers their win rate by -3.2% to 47.1%. This clearly indicates that there is a very bad strategic relationship between Cassiopeia and Karthus that allows them to perform worse together than alone.
Karthus has a much lower diffuclty than Cassiopeia. That means Cassiopeia players don't need to be careful when enlisting Karthus comrades to go into battle on the same side as, as they will require a much lower level of skill to work well with you.
Fighting on the same side, Cassiopeia players should see an overall large increase in your team’s capability to deal magic damage. When paired, these champs can deal quite a lot of AP type damage.
Conversely, by grouping Cassiopeia and Karthus together, you may not be giving your team enough AD. Make sure to bring other champs on your team that fills this gap in this pairing's capabilities.
Regardless of the ability of your Karthus ally, you need to focus on increasing your income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Cassiopeia to synergize with Karthus during both the lane and mid / late game phases of League of Legends rounds, you should continue reading to learn some more tricks and insights into this champion pairing. If you mind the build and tips displayed above, you will increase your win rate by a lot.
The top finished items to have in your Cassiopeia and Karthus synergy build include Umarmung des Seraphen, Liandrys Qual, and Stab der Zeitalter. When Cassiopeia used at least these three pieces in her build, she performed much better when paired up with Karthus than with many other commonly used builds. In fact, Cassiopeia had an average winrate of 47.1% when playing alongside Karthus with these items in her kit.
To have the highest probability of crushing your oponents, Cassiopeia players should equip the Eroberer, Geistesgegenwart, Legende: Zähigkeit, Letztes Gefecht, Manafluss, and Überlegenheit runes from the Präzision and Zauberei rune sets. Out of all the rune builds players picked for this champion pairing, this blending of runes resulted in the best win rate. Notably, these runes averaged a 47.1% win rate overall.
If you would like to see Cassiopeia with Karthus synergy tips and builds for a a distinct division rank, please select one from the selection menu above. By default, the statistics and strategies given are calculated using all games run with these champions.