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The stats provided here feature some vital Karthus vs. Seraphine matchup statistics that can help you understand the differences and similarities between the pair. As an example, Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Seraphine’s KDA ratio of NaN, showing that Karthus may be more central to his team's team fighting capacity than Seraphine. This observation is largely fueled by the difference in kills.
Karthus often has a slightly larger longest kill spree than his opponent does. Typically, he receives more damage than Seraphine. This typically indicates different amounts of tankyness; however, it can also show that the champ with higher health has less agility and thus is not able to escape further damage when engaged or poked.
Both League champions are great. Both have their pros and cons. In League's current meta, Karthus usually loses when playing against Seraphine, with a 47.5% win rate. Therefore, Karthus makes a bad counter to Seraphine.
While Karthus does have a lower win rate compared to Seraphine, when they face off with one another, Karthus also has a much greater level of difficulty that makes him a more difficult character to pick up and master. You should expect to face a difficult match when picking Karthus into Seraphineas his relative depth means you may not be able to reach his full potential without a significant amount of practice beforehand.
Furthermore, Karthus also has some amount of utility and CC, a similar amount to Seraphine. This makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there isn't a single best champion in League of Legends, in Karthus vs Seraphine matchups, Seraphine is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your team members during late stage team fights.
Karthus is a terribly counter for Seraphine. Make sure you focus your strategy on keeping up your gold and cs and taking out objectives. If you are able to do that, you should hold your own as Karthus against Seraphine.
If you would like to truly master Karthus to counter Seraphine during both the lane and mid / late game phases of League of Legends, you should keep reading to learn a few extra tips and tricks for this matchup. If you pay attention to the build and tips presented here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Karthus most often picks up a similar amount of CS relative to Seraphine. Champions who on average don't get much CS often don't require much CS to be valuable teammates, such as supports. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often need many items to be effective. In either situation, try to do better than the values displayed on this page to do well.
The top items to use in your Karthus versus Seraphine build consist of Rabadons Todeshaube, Bösartigkeit, and Liandrys Qual. When Karthus incorporated at least these three items in his build, he performed much better vs Seraphine than with many other typical counter builds. In fact, Karthus had an average winrate of 47.5% when countering Seraphine with this counter build.
To have the greatest likelihood of coming out on top against Seraphine as Karthus, Karthus players should use the Dunkle Seelenernte, Perfider Trick, Argus' Vermächtnis, Ultimativer Jäger, Geistesgegenwart, and Letztes Gefecht runes from the Dominanz and Präzision rune sets. Of all the rune sets players picked for Karthus vs Seraphine counters, this combination of runes resulted in the best win rate. In fact, these runes gave a 47.5% win rate overall.
If you need to view Karthus x Seraphine tips and counter stats for a an individual division rank, feel free to choose one from the selection menu provided above. If viewing for the first time, the statistics and build suggestions given are computed using every round run with both champs.