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The stat comparisons provided here highlight some influential Karthus vs. Senna matchup stats that may help us interpret the differences and similarities between the two. Karthus’s KDA ratio ([kills + assists] / deaths) of NaN is more than Senna’s ratio of NaN, demonstrating that Karthus may be more central to his team's team fighting effectiveness than Senna..
Karthus typically has a slightly larger longest killing spree than his foe does. Commonly, he receives more damage than Senna. This often reflects differing health capacities; however, it can also imply that the champ with more HP has less mobility and thus is not able to escape additional damage when engaged or poked.
Both League champions are great champions. Both have their pros and cons. In the game's current meta, Karthus usually loses when playing against Senna, with a 46.5% win rate. Thus, Karthus makes a poor counter for Senna.
While Karthus does have a lower win rate compared to Senna, when on opposite teams, Karthus also has a greater learning curve that makes him a more challenging champion to learn. You should expect to face a difficult match when picking Karthus into Sennaas his relative depth means you may not be able to reach his full potential without a lot of practice beforehand.
Moreover, Karthus also has some amount of utility and CC, a similar amount to Senna. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Karthus vs Senna matchups, Senna is the better champ with a much lower win rate, similar champion depth, and a similar amount of utility to help out your teammates during team fights.
Karthus is a bad counter to Senna. You will do well by focussing your actions on maximizing your gold income and destroying objectives. If you are able to do that, you should do very well as Karthus against Senna.
If you would like to learn all of the intricacies of Karthus in order to counter Senna during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you pay attention to the build and suggestions presented above, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Karthus often picks up a similar amount of CS relative to Senna. Champs who on average don't get much CS usualy don't have to have much CS to be effective, such as support champions. They are able to scale properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually have to have a lot of items to be effective. In either situation, try to surpass the values displayed on this page to do well.
The best items to use in your Karthus versus Senna build include Rabadons Todeshaube, Bösartigkeit, and Zhonyas Stundenglas. When Karthus bought at least these three pieces in his build, he did significantly better against Senna than with many other commonly used counter builds. In fact, Karthus boasted an average winrate of 46.5% when playing against Senna with this build.
To have the best chance of annihilating Senna as Karthus, Karthus players should take the Dunkle Seelenernte, Perfider Trick, Argus' Vermächtnis, Schatzjäger, Gnadenstoß, and Geistesgegenwart runes from the Dominanz and Präzision rune sets. Out of all the rune sets players chose for Karthus vs Senna counter picks, this mixture of runes resulted in the highest win rate. Moreover, these runes provided a 46.5% win rate overall.
If you want to view Karthus versus Senna tips and counter stats for a a specific rank, feel free to choose one from the selection menu displayed above. If viewing for the first time, the stats and guides shown are computed using all rounds finished with these champions.