The greatest champions out of lane to counter Twitch include Taliyah, Volibear, and Karthus. These champions are all good at countering Twitch with high win rates over 55%. Even if these Twitch counter picks are not taken opposite your position, it's not a good idea to play him into any of these matchups. They will likely destroy Twitch.
Yet, if the other team choses either Teemo or Fizz, Twitch mains should strongly think about selecting him, as he easily beats these champions with win rates over 56% against each ofthem.
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