League of Legends Seraphine players will find her to be a difficult champion to build out properly. You will notice that her build varies when she is up against either diversified or specialized team comps, meaning you shouldn't follow the same Seraphine build every single round of League of Legends
The most important items to incorporate into your champion's build include: Echos von Helia, Rylais Kristallzepter, and Thymiaterion. Those who included these pieces in their setups had a significantly better winrate than players who worked towards other Seraphine builds. Likewise, if you are trying to beat a varied enemy team arrangement, you should really consider grabbing her the Zauberei, and Inspiration runes. In recent matches, she won the greatest number of her matches when built with these runes.
We established our Seraphine build suggestions by examining 91.837 recently ranked LoL rounds with her in them. We only recommend the highest winrate Seraphine builds that were built by ranked League players enough times for us to propose them. With so many rounds in our dataset, we are very confident in our recommended builds.