The best champions globally to counter Nautilus include Kai'Sa, Kalista, and Tristana. These champions are all great at countering Nautilus with high win rates over 57%. Even if these Nautilus counter picks are not played in your lane, it's not smart to choose him into any of these matchups. They will often destroy Nautilus.
Conversely, if the enemy team picks either Rumble or Lillia, you should seriously consider choosing him, as he easily beats these champions with win rates over 54% against each ofthem.
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