Seeds grant vision to your team.
Placing a seed in your spell's path after you have cast it gives you the best chance of having a seed in the proper spot.
Zyra is a great ambusher - look for opportunities to set a trap of seeds in brush, then lure enemies in.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats provided here show some significant Zyra versus Karthus counter statistics that can help us distinguish the differences and similarities between the two. For instance, Zyra’s KDA ratio ([kills + assists] / deaths) of NaN is more than Karthus’s KDA ratio of NaN, demonstrating that Zyra may be more central to her team's team fighting capacity than Karthus..
Zyra typically has a significantly smaller longest kill spree than her enemy does. Commonly, she takes less damage than Karthus. This often reflects different amounts of tankyness, but it can also hint that the champ with increased health has less agility and thus is unable to escape further damage when engaged or poked.
Both League of Legends champions are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Zyra usually wins when playing against Karthus, with a 54.3% win rate. As a result, Zyra makes a great counter to Karthus.
While Zyra does have a much higher win rate than Karthus, when facing one another, Zyra also has a greater difficulty level that makes her a more time consuming character to develop with. You should be be fine when picking Zyra into Karthusas her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Additionally, Zyra also has some amount of CC and other utility, a similar amount to Karthus. This makes her just as valuable during team fights, especially when fighting champions with a ton of burst damage.
While there is not a single best champion overall in League of Legends, in Zyra vs Karthus matchups, Zyra is the better champion with a noticably higher win rate, similar champion depth, and a similar amount of utility to help out your team members during team fights.
Zyra is a great counter for Karthus. You will do well by focussing your play on keeping up your gold and cs and destroying objectives. If you are able to do that, you should hold your own as Zyra against Karthus.
To truly master Zyra to counter Karthus during both the early game and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you listen to the build and suggestions displayed above, you should increase your win rate by a lot and be that much closer to League of Legends pro players.
Zyra usually racks up less CS relative to Karthus. Champs who typically don't earn much CS typically don't need much CS to be valuable teammates, such as sup champs. They are capable of scaling properly off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often have to have a lot of items to be effective. In either case, try to surpass the values shown on this page to do well.
The most important items to use in your Zyra versus Karthus build include Rylai's Crystal Scepter, Zaz'Zak's Realmspike, and Liandry's Torment. When Zyra combined at least these three pieces in her build, she performed significantly better countering Karthus than with most other common builds. In fact, Zyra boasted an average win rate of 54.3% when countering Karthus with this build.
To have the highest probability of annihilating Karthus as Zyra, you should use the Arcane Comet, Manaflow Band, Transcendence, Scorch, Relentless Hunter, and Taste of Blood runes from the Sorcery and Domination rune sets. Out of all the rune sets players picked for Zyra vs Karthus fights, this mixture of runes yielded the greatest win rate. In fact, these runes averaged a 54.3% win rate overall.
If you want to get Zyra versus Karthus tips and counter builds for a a particular division, feel free to choose one from the selection menu displayed above. At first, the stats and build suggestions given are calculated using all games with data with both champions.