Sleepy Trouble Bubble travels further over walls. Find a hiding spot to set up for a long distance kill.
Break Sleep with your biggest damage source, since enemies who are asleep take double damage.
Paddle Star deals more damage the further it has flown. Casting it behind yourself before redirecting can deal tons of damage.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown here feature some significant Zoe versus Vayne matchup statistics that may help us realize the differences and similarities between the pair. Zoe’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vayne’s ratio of NaN, indicating that Zoe may be more central to her team's team fighting potential than Vayne..
Zoe typically has a similar longest kill spree as her enemy does. On average, she takes a similar amount of damage to Vayne. This is usually reflective of differing health capacities, yet it can also hint that the one champ has less mobility and thus is not able to escape further harm when poked or engaged.
Both LoL champs are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Zoe usually loses when taking on Vayne, with a 47.9% win rate. Therefore, Zoe makes a bad counter for Vayne.
While Zoe does have a lower win rate compared to Vayne, when facing one another, Zoe also has a lower level of difficulty that makes her a less difficult character to pick up and master. You may get destroyed when picking Zoe into Vayne.
Moreover, Zoe also has almost no amount of CC and other utility, a similar amount to Vayne. This makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there isn't a single best champion in League of Legends, in Zoe vs Vayne matchups, Vayne is the better champ with a lower win rate, less champion complexity, and a similar amount of utility to help out your allies during teamfights.
Zoe is a garbage counter to Vayne. Make sure you focus your play on keeping up your gold and cs and destroying objectives. If you can do that, you should do very well as Zoe against Vayne.
If you would like to truly master Zoe to counter Vayne during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra tricks and insights into this matchup. If you mind the build and suggestions presented above, you will grow your win rate by a lot and be closer to League of Legends pro players.
Zoe on average gets a similar amount of CS as Vayne. Champs who typically don't get much CS often don't require much CS to be effective, such as supports. They are able to scale properly off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically need a lot of items to be effective. In either case, try to do better than the values displayed on this page to do well.
The ideal items to prioritize in your Zoe versus Vayne build include Horizon Focus, Stormsurge, and Luden's Companion. When Zoe used at least these three pieces in her build, she did significantly better when facing Vayne than with many other commonly used item sets. In fact, Zoe boasted an average win rate of 47.9% when countering Vayne with these items in her kit.
To have the highest likelihood of annihilating Vayne as Zoe, you should equip the Electrocute, Taste of Blood, Eyeball Collection, Treasure Hunter, Manaflow Band, and Scorch runes from the Domination and Sorcery rune sets. Of all the rune combinations players used for Zoe vs Vayne fights, this order of runes yielded the best win rate. In fact, these runes gave a 47.9% winrate overall.
By default, tips, stats, and builds on how to beat Vayne as Zoe are presented for every ranked division. To filter the statistics and builds to an individual player tier, you can use the selection menu earlier in the counter matchup guide.