Sleepy Trouble Bubble travels further over walls. Find a hiding spot to set up for a long distance kill.
Break Sleep with your biggest damage source, since enemies who are asleep take double damage.
Paddle Star deals more damage the further it has flown. Casting it behind yourself before redirecting can deal tons of damage.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons shown on this page show several critical Zoe versus Karthus matchup stats that can help you appreciate the differences and similarities between these two champs. As an example, Zoe’s KDA ratio ([kills + assists] / deaths) of NaN is more than Karthus’s ratio of NaN, indicating that Zoe may be more central to her team's team fighting capability than Karthus..
Zoe typically has a similar longest kill spree as her enemy does. Typically, she takes less damage than Karthus. This is usually reflective of different amounts of tankyness, yet it can also show that the champ with increased HP has less mobility and thus is not able to kite away from further harm when engaged or poked.
Both League champions are great. Both champs have their strengths, weaknesses, and counters. In League's current meta, Zoe usually loses when facing off against Karthus, with a 48.1% win rate. Therefore, Zoe makes a bad counter for Karthus.
While Zoe does have a lower win rate compared to Karthus, when they face off with one another, Zoe also has a lower difficulty level that makes her a less complex character to develop with. You still need to be cautious when picking Zoe into Karthus.
Furthermore, Zoe has almost no amount of utility and CC, a similar amount to Karthus. This often makes her just as valuable during teamfights, especially when fighting champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Zoe vs Karthus matchups, Karthus is the better champ with a lower win rate, less champion complexity, and a similar amount of utility to help out your allied champions during teamfights.
Zoe is a somewhat poor counter for Karthus. Make sure you focus your actions on maximizing your gold and cs and taking out objectives. If you are able to do that, you should hold your own as Zoe against Karthus.
To truly master Zoe in order to counter Karthus during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tips and tricks for this matchup. If you pay attention to the build and stats presented above, you should increase your win rate significantly and be closer to League of Legends pro players.
Zoe most often accumulates more CS compared to Karthus. Champs who typically don't acquire many minion kills usualy don't need much CS to be valuable teammates, such as sup champs. They are capable of scaling well off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually require several high cost items to be effective. In either situation, try to surpass the values reported here to do well.
The most crucial items to have in your Zoe versus Karthus build include Rabadon's Deathcap, Stormsurge, and Luden's Companion. When Zoe included at least these three pieces in her build, she performed a lot better versus Karthus than with many other commonly used item sets. In fact, Zoe had an average win rate of 48.1% battling Karthus with these items in her kit.
To have the greatest chance of crushing Karthus as Zoe, Zoe players should equip the Electrocute, Taste of Blood, Eyeball Collection, Treasure Hunter, Manaflow Band, and Scorch runes from the Domination and Sorcery rune sets. Out of all the rune combinations players picked for Zoe vs Karthus counter picks, this blending of runes yielded the greatest win rate. Moreover, these runes gave a 48.1% winrate overall.
If you would like to see Zoe x Karthus tips and builds for a a particular division, feel free to choose one from the selection menu provided above. If viewing for the first time, the statistics and guides displayed are computed using all matches with data with these champs.