Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown here emphasize some significant Zeri versus Vayne matchup statistics that may help you realize the differences and similarities between the pair. Zeri’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s ratio of NaN, highlighting that Zeri may be more central to their team's team fighting capacity than Vayne..
Zeri usually has a similar longest kill spree as their matchup does. Commonly, they receives a similar amount of damage to Vayne. This is usually reflective of differing health capacities; however, it can also show that the champion with increased HP has less mobility and thus is not able to kite away from further harm when engaged or poked.
Both LoL champs are great. Both champs have their pros and cons. In the game's current meta, Zeri usually loses when trying to fight Vayne, with a 45.2% win rate. Therefore, Zeri makes a poor counter for Vayne.
While Zeri does have a much lower winrate compared to Vayne, when on opposite teams, Zeri also has a lower difficulty level that makes them a less challenging character to learn and master. You should be very concerned when picking Zeri into Vayne.
Moreover, Zeri has some amount of utility and CC, a similar amount to Vayne. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not one best champion for every situation in League of Legends, in Zeri vs Vayne matchups, Vayne is the better champ with a much lower win rate, less champion complexity, and a similar amount of utility to help out your allies during late stage team fights.
Zeri is a bad counter to Vayne. Make sure you focus your strategy on keeping up your gold and cs and taking out objectives. If you can do that, you should hold your own as Zeri against Vayne.
To truly master Zeri to counter Vayne during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you mind the build and tips presented above, you should grow your win rate by a lot and be that much closer to League of Legends pro players.
Zeri on average racks up a similar amount of CS as Vayne. Champs who on average don't get many minion kills typically don't require much CS to be valuable teammates, such as sup champs. These kinds of champions are capable of scaling properly off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually have to have several high cost items to be effective. In either case, try to do better than the values shown on this page to do well.
The best items to focus on in your Zeri versus Vayne build include Bloodthirster, Experimental Hexplate, and Titanic Hydra. When Zeri incorporated at least these three items in their build, they did a lot better vs. Vayne than with most other common counter builds. In fact, Zeri had an average winrate of 45.2% battling Vayne with these items in their kit.
To have the highest probability of coming out on top against Vayne as Zeri, Zeri players should use the Lethal Tempo, Triumph, Legend: Alacrity, Last Stand, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune sets players chose for Zeri vs Vayne face-offs, this mixture of runes yielded the highest win rate. Moreover, these runes gave a 45.2% winrate overall.
By default, tips, stats, and builds on how to beat Vayne as Zeri are given for all ranked divisions. If you would like to filter the stats and builds to a particular rank, you should use the selection menu located earlier on the page.