Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats shown on this page highlight several strategic Zeri versus Karthus counter statistics that may help you interpret the differences between this set of champions. For instance, Zeri’s KDA ratio ([kills + assists] / deaths) of NaN is better than Karthus’s ratio of NaN, demonstrating that Zeri may be more central to their team's team fighting effectiveness than Karthus..
Zeri normally has a similar longest kill spree as their counter does. Typically, they receives a similar amount of damage to Karthus. This is usually reflective of different amounts of tankyness; however, it can also indicate that the champ with higher health has less mobility and thus is unable to flee from additional damage when engaged or poked.
Both League champs are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Zeri usually loses when facing off against Karthus, with a 47.2% win rate. Thus, Zeri makes a bad counter for Karthus.
While Zeri does have a lower win rate compared to Karthus, when they face off with one another, Zeri also has a lower learning curve that makes them a less challenging champ to learn and master. You should be very concerned when picking Zeri into Karthus.
Furthermore, Zeri also has some amount of utility and CC, a similar amount to Karthus. This often makes her just as valuable during teamfights, especially when fighting champions with a lot of burst damage.
While there isn't a single best champion in League of Legends, in Zeri vs Karthus matchups, Karthus is the better champion with a lower win rate, less champion complexity, and a similar amount of utility to help out your allies during late stage team fights.
Zeri is a bad counter to Karthus. You will do well by focussing your strategy on maximizing your CS and taking out objectives. If you can do that, you should hold your own as Zeri against Karthus.
If you would like to truly master Zeri to counter Karthus during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra tips and tricks for this matchup. If you listen to the build and suggestions shown here, you should grow your win rate significantly and be that much closer to League of Legends pro players.
Zeri usually racks up more CS relative to Karthus. Champions who on average don't get much CS often don't need much CS to be effective, such as supports. These kinds of champions are capable of scaling properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often have to have a lot of items to be effective. In either case, try to do better than the numbers displayed on this page to do well.
The best items to focus on in your Zeri versus Karthus build consist of Experimental Hexplate, Runaan's Hurricane, and Navori Quickblades. When Zeri bought at least these three pieces in their build, they did a lot better vs. Karthus than with most other commonly used item sets. In fact, Zeri had an average winrate of 47.2% when playing against Karthus with this counter build.
To have the best probability of annihilating Karthus as Zeri, you should equip the Lethal Tempo, Triumph, Legend: Alacrity, Last Stand, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune combinations that we analyzed for Zeri vs Karthus battles, this mix of runes yielded the highest win rate. Moreover, these runes gave a 47.2% win rate overall.
If you want to get Zeri vs Karthus tips and counter stats for a a distinct division, please choose one from the selection menu shown above. By default, the statistics and strategies shown are computed using all matches finished with these champs.