Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Zilean is fragile if a team focuses on him, but otherwise he's very difficult to kill. Commit to killing him as a team.
If you're able to match Zilean's speed, it can sometimes be beneficial to wait until his ultimate has faded before landing the killing blow.
The stat comparisons provided here clarify some important Vayne versus Zilean counter stats that can help you interpret the differences and similarities between the two. Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is better than Zilean’s KDA ratio of NaN, highlighting that Vayne may be more central to her team's team fighting effectiveness than Zilean. This observation is largely caused by the difference in kills.
Vayne usually has a much larger longest killing spree than her opponent does. On average, she receives more damage than Zilean. This typically indicates different amounts of tankyness, yet it can also hint that the champ with higher health has less agility and thus is unable to kite away from further harm when engaged or poked.
Both League champs are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Vayne usually loses when playing against Zilean, with a 48.6% win rate. As a result, Vayne makes a bad counter for Zilean.
While Vayne does have a lower win rate than Zilean, when they face off with one another, Vayne also has a greater level of difficulty that makes her a more challenging character to learn. You still need to be cautious when picking Vayne into Zileanas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Furthermore, Vayne also has some amount of utility and CC, a similar amount to Zilean. This makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there isn't one best champion in League of Legends, in Vayne vs Zilean matchups, Zilean is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your teammates during teamfights.
Vayne is a somewhat poor counter to Zilean. Make sure you focus your play on keeping up your gold and cs and destroying objectives. If you can do that, you should do very well as Vayne against Zilean.
If you would like to truly master Vayne to counter Zilean during both the lane and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you pay attention to the build and stats shown above, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Vayne typically racks up more CS relative to Zilean. Champions who typically don't acquire many minion kills usualy don't require much CS to be valuable teammates, such as supports. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often require a lot of items to be effective. In either case, try to surpass the values reported here to do well.
The most crucial items to focus on in your Vayne versus Zilean build include Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne used at least these three pieces in her build, she did significantly better vs. Zilean than with many other common builds. In fact, Vayne boasted an average winrate of 48.6% when playing against Zilean with these items in her kit.
To have the best probability of crushing Zilean as Vayne, you should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune sets players picked for Vayne vs Zilean counters, this set of runes resulted in the highest win rate. Moreover, these runes provided a 48.6% win rate overall.
By default, tips, stats, and builds on how to beat Zilean as Vayne are presented for every ranked division. If you would like to narrow the statistics and builds to a particular player tier, you may use the selection menu located earlier on the page.