Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The stats shown on this page clarify several significant Vayne vs. Senna counter statistics that may help us grasp the differences and similarities between this set of champs. As an example, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is more than Senna’s ratio of NaN, showing that Vayne may be more central to her team's team fighting capability than Senna..
Vayne usually has a slightly larger longest kill spree than her foe does. On average, she receives more damage than Senna. This is usually reflective of differing health capacities, but it can also illustrate that the one champion has less mobility and thus is not able to escape further damage when engaged or poked.
Both LoL champs are great champions. Both champs have their pros and cons. In the game's current meta, Vayne usually loses when trying to fight Senna, with a 48.1% win rate. Thus, Vayne makes a bad counter to Senna.
While Vayne does have a lower win rate compared to Senna, when on opposite teams, Vayne also has a greater level of difficulty that makes her a more complex champion to pick up and master. You should be careful when picking Vayne into Sennaas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Additionally, Vayne also has some amount of utility and CC, a similar amount to Senna. This often makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there is not a single best champion overall in League of Legends, in Vayne vs Senna matchups, Senna is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your allies during team fights.
Vayne is a somewhat poor counter for Senna. Make sure you focus your strategy on keeping up your gold and cs and taking out objectives. If you are able to do that, you should do very well as Vayne against Senna.
If you would like to learn all of the intricacies of Vayne in order to counter Senna during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you listen to the build and stats displayed here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Vayne typically picks up more CS compared to Senna. Champs who on average don't earn many minion kills often don't need much CS to be effective, such as support champions. These kinds of champions are capable of scaling properly off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often need several high cost items to be effective. In either case, try to exceed the values displayed on this page to do well.
The best items to prioritize in your Vayne versus Senna build consist of Experimental Hexplate, Guinsoo's Rageblade, and Terminus. When Vayne used at least these three items in her build, she performed significantly better against Senna than with most other typical item sets. In fact, Vayne boasted an average win rate of 48.1% battling Senna with these items in her kit.
To have the highest chance of annihilating Senna as Vayne, you should use the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Overgrowth, and Conditioning runes from the Precision and Resolve rune sets. Out of all the rune sets we have analyed for Vayne vs Senna clashes, this combination of runes yielded the highest win rate. In fact, these runes provided a 48.1% winrate overall.
If you would like to see Vayne x Senna tips and counter stats for a a distinct division rank, feel free to choose one from the selection menu provided above. By default, the statistics and guides displayed are computed using all matches finished with both champions.