Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Pantheon's Aegis Assault makes him invulnerable from the front. Get behind him or wait it out.
Grand Starfall gives several seconds of warning before Pantheon arrives. Use this time to get out of the way or to form a plan to deal with him.
Be careful near Pantheon if your health is low - a thrown Comet Spear executes low health enemies.
The stat comparisons shown here feature some critical Vayne versus Pantheon matchup stats that may help us understand the differences and similarities between the two. As an example, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Pantheon’s ratio of NaN, showing that Vayne may be more central to her team's team fighting effectiveness than Pantheon..
Vayne often has a similar longest kill spree as her foe does. On average, she takes less damage than Pantheon. This often reflects different amounts of tankyness; however, it can also hint that the one champ has less agility and thus is unable to escape additional damage when engaged or poked.
Both League of Legends champions are great champions. Both have their strengths, weaknesses, and counters. In League's current meta, Vayne usually fairs equally well when facing off against Pantheon, with a 50.5% win rate. Therefore, Vayne makes an ok counter to Pantheon.
While Vayne does have a higher win rate compared to Pantheon, when on opposite teams, Vayne also has a much greater level of difficulty that makes her a more difficult champion to learn. You still need to be cautious when picking Vayne into Pantheonas her relative depth means that you may not be able to reach her full potential without a significant amount of practice beforehand.
Additionally, Vayne has some amount of CC and other utility, a similar amount to Pantheon. This often makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there isn't a single best champion for every situation in League of Legends, in Vayne vs Pantheon matchups, Vayne is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your allied champions during teamfights.
Vayne is a decent counter for Pantheon. You will do well by focussing your actions on keeping up your gold and cs and taking out objectives. If you are able to do that, you should hold your own as Vayne against Pantheon.
If you would like to learn all of the intricacies of Vayne to counter Pantheon during both the laning and mid / late game phases of League of Legends, you should continue reading to gather a few extra tricks and insights into this matchup. If you listen to the build and stats presented above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Vayne on average racks up more CS relative to Pantheon. Champions who typically don't take much CS usualy don't have to have much CS to be valuable teammates, such as support champions. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either situation, try to do better than the numbers displayed here to do well.
The ideal items to focus on in your Vayne versus Pantheon build include Guinsoo's Rageblade, Terminus, and Jak'Sho, The Protean. When Vayne combined at least these three items in her build, she did much better against Pantheon than with most other commonly used item sets. In fact, Vayne had an average winrate of 50.5% battling Pantheon with this counter build.
To have the highest likelihood of beating Pantheon as Vayne, you should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune combinations players chose for Vayne vs Pantheon face-offs, this set of runes resulted in the highest win rate. Notably, these runes provided a 50.5% winrate overall.
If you need to see Vayne versus Pantheon tips and counter builds for a an individual division, feel free to choose one from the selection menu displayed above. At first, the stats and guides shown are calculated using all rounds run with these champs.