Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Catching Milio with no allies around severely inhibits his mobility. Try to find him alone.
Champions with crowd control that can be applied quickly excel against Milio.
Milio's movement abilities forecast their destination. Try to use this to your advantage.
The stats shown here clarify several critical Vayne versus Milio counter statistics that can help us distinguish the differences between the pair. Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is better than Milio’s ratio of NaN, showing that Vayne may be more central to her team's team fighting capacity than Milio. This observation is in large part a result of the difference in kills.
Vayne usually has a much larger longest kill spree than her counter does. On average, she takes more damage than Milio. This commonly reflects differing health capacities; however, it can also illustrate that the champ with increased HP has less agility and thus is unable to flee from further damage when poked or engaged.
Both LoL champs are great. Both have their pros and cons. In League's current meta, Vayne usually loses when facing off against Milio, with a 48.6% win rate. Therefore, Vayne makes a poor counter to Milio.
While Vayne does have a lower winrate compared to Milio, when on opposite teams, Vayne also has a much greater difficulty level that makes her a more time consuming character to pick up and master. You still need to be cautious when picking Vayne into Milioas her relative depth means that you may not be able to unleash her full potential without a lot of practice beforehand.
Furthermore, Vayne also has some amount of utility and CC, a similar amount to Milio. This makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there isn't a single best champion overall in League of Legends, in Vayne vs Milio matchups, Milio is the better champ with a lower win rate, more champion depth, and a similar amount of utility to help out your teammates during teamfights.
Vayne is a somewhat poor counter to Milio. You will do well by focussing your actions on increasing your gold income and clearing objectives. If you can do that, you should hold your own as Vayne against Milio.
If you would like to truly master Vayne in order to counter Milio during both the lane and mid / late game phases of League of Legends, you should continue reading to learn a few extra lessons on this matchup. If you pay attention to the build and suggestions shown above, you will grow your win rate by a lot and be closer to League of Legends pro players.
Vayne often gets much more CS compared to Milio. Champs who typically don't get many minion kills often don't require much CS to be valuable teammates, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, typically need many items to be effective. In either situation, try to surpass the numbers reported here to do well.
The most important items to use in your Vayne versus Milio build include Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne bought at least these three items in her build, she performed significantly better when facing Milio than with most other common counter builds. In fact, Vayne boasted an average win rate of 48.6% battling Milio with this counter build.
To have the greatest chance of defeating Milio as Vayne, you should use the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the runes players used for Vayne vs Milio fights, this mixture of runes yielded the greatest win rate. Moreover, these runes averaged a 48.6% winrate overall.
If you need to view Vayne x Milio tips and counter builds for a a distinct player tier, feel free to choose one from the selection menu displayed above. If viewing for the first time, the stats and strategies shown are calculated using all games run with both champions.