Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
It takes 6 spell casts for Kassadin's slow, Force Pulse, to become castable. If he levels up that ability, judiciously use your own skills while laning against him.
Kassadin deals mostly magic damage. If he's doing well consider buying magic resist items like Mercury's Treads and Banshee's Veil.
Each time Kassadin consecutively uses Riftwalk, he pays more and more mana. Keep this in mind as you chase him.
The stats shown on this page feature several critical Vayne against Kassadin matchup stats that can help us explain the differences between the two. For instance, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Kassadin’s KDA ratio of NaN, demonstrating that Vayne may be more central to her team's team fighting capacity than Kassadin..
Vayne often has a similar longest kill spree as her enemy does. Typically, she takes less damage than Kassadin. This is usually reflective of different amounts of tankyness, yet it can also illustrate that the one champion has less mobility and thus is unable to kite away from additional harm when engaged or poked.
Both League champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Vayne usually fairs equally well when trying to fight Kassadin, with a 50.8% win rate. Thus, Vayne makes an ok counter to Kassadin.
While Vayne does have a higher winrate than Kassadin, when on opposite teams, Vayne also has a greater level of difficulty that makes her a more time consuming character to pick up and master. You should be careful when picking Vayne into Kassadinas her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Furthermore, Vayne has some amount of utility and CC, a similar amount to Kassadin. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there is not a single best champion for every situation in League of Legends, in Vayne vs Kassadin matchups, Vayne is the better champ with a similar win rate, similar champion depth, and a similar amount of utility to help out your team members during teamfights.
Vayne is a decent counter to Kassadin. Make sure you focus your play on maximizing your CS and destroying objectives. If you do that, you should hold your own as Vayne against Kassadin.
If you would like to truly master Vayne to counter Kassadin during both the lane and mid / late game phases of League of Legends, you should continue reading to gather a few extra lessons on this matchup. If you listen to the build and stats presented here, you will increase your win rate significantly and be closer to League of Legends pro players.
Vayne typically gets a similar amount of CS relative to Kassadin. Champions who on average don't take much CS usualy don't need much CS to be effective, such as supports. They are capable of scaling properly off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often require several high cost items to be effective. In either case, try to do better than the numbers shown here to do well.
The most important items to use in your Vayne versus Kassadin build consist of Wit's End, Blade of The Ruined King, and Kraken Slayer. When Vayne included at least these three items in her build, she performed a lot better when facing Kassadin than with many other commonly used builds. In fact, Vayne boasted an average winrate of 50.8% when playing against Kassadin with this counter build.
To have the best probability of defeating Kassadin as Vayne, Vayne players should take the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune builds players picked for Vayne vs Kassadin fights, this sequence of runes resulted in the best win rate. In fact, these runes gave a 50.8% winrate overall.
If you want to get Vayne x Kassadin tips and counter builds for a a distinct player tier, feel free to choose one from the selection menu provided above. If viewing for the first time, the statistics and guides shown are calculated using all games played with these champs.