Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons provided here emphasize several strategic Vayne vs. Karthus matchup stats that can help us distinguish the differences and similarities between the pair. For instance, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s ratio of NaN, showing that Vayne may be more central to her team's team fighting effectiveness than Karthus..
Vayne typically has a similar longest killing spree as her opponent does. Typically, she takes less damage than Karthus. This typically indicates different amounts of tankyness; however, it can also hint that the one champ has less agility and thus is not able to escape additional harm when engaged or poked.
Both League of Legends champions are great. Both champs have their pros and cons. In League's current meta, Vayne usually wins when playing against Karthus, with a 53.0% win rate. Thus, Vayne makes a good counter for Karthus.
While Vayne does have a higher win rate than Karthus, when facing one another, Vayne also has a greater difficulty level that makes her a more complex champion to learn and master. You should be be fine when picking Vayne into Karthusas her relative depth means you may not be able to unleash her full potential without a significant amount of practice beforehand.
Furthermore, Vayne has some amount of CC and other utility, a similar amount to Karthus. This makes her just as valuable during team fights, especially when trying to counter champions with a lot of burst damage.
While there is not one best champion for every situation in League of Legends, in Vayne vs Karthus matchups, Vayne is the better champ with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your teammates during late stage team fights.
Vayne is an above average counter to Karthus. Make sure you focus your play on increasing your CS and clearing objectives. If you can do that, you should be able to stand on your own as Vayne against Karthus.
To truly master Vayne in order to counter Karthus during both the early game and mid / late game phases of League of Legends, you should keep reading to pick up a few extra tips and tricks for this matchup. If you listen to the build and stats displayed here, you will increase your win rate significantly and be that much closer to League of Legends pro players.
Vayne most often accumulates more CS compared to Karthus. Champs who on average don't take much CS typically don't have to have much CS to be valuable teammates, such as supports. These kinds of champions are capable of scaling well off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often need many items to be effective. In either case, try to surpass the numbers displayed on this page to do well.
The most crucial items to have in your Vayne versus Karthus build include Guinsoo's Rageblade, Blade of The Ruined King, and Kraken Slayer. When Vayne combined at least these three items in her build, she performed much better against Karthus than with many other common item sets. In fact, Vayne boasted an average win rate of 53.0% when countering Karthus with this counter build.
To have the greatest probability of annihilating Karthus as Vayne, Vayne players should use the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the runes players chose for Vayne vs Karthus fights, this set of runes yielded the best win rate. Notably, these runes provided a 53.0% winrate overall.
By default, tips, stats, and builds on how to beat Karthus as Vayne are presented for all skill levels combined. If you want to narrow the stats and builds to a distinct division, you may use the selection menu earlier on the page.