Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Focused Resolve is a strong disengage tool. Create distance to avoid being rooted and seek to engage afterwards.
Karma's Soulflare erupts for bonus damage in the area in which it's placed. React quickly and escape the circle to avoid taking heavy damage.
Karma's passive lowers her Mantra cooldown when she hits enemy champions with abilities and basic attacks. Deny her from getting free hits on you.
The stat comparisons provided here feature several significant Vayne versus Karma matchup statistics that can help you distinguish the differences and similarities between the pair. As an example, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is better than Karma’s ratio of NaN, highlighting that Vayne may be more central to her team's team fighting capacity than Karma. This observation is largely caused by the difference in kills.
Vayne normally has a much larger longest killing spree than her enemy does. Typically, she receives more damage than Karma. This often reflects differing health capacities; however, it can also illustrate that the champ with higher HP has less mobility and thus is unable to escape additional damage when engaged or poked.
Both LoL champions are great. Both have their pros and cons. In League's current meta, Vayne usually wins when taking on Karma, with a 52.7% win rate. As a result, Vayne makes a good counter for Karma.
While Vayne does have a higher winrate than Karma, when facing one another, Vayne also has a much greater learning curve that makes her a more complex champ to develop with. You don't need to be too worried when picking Vayne into Karmaas her relative depth means that you may not be able to reach her full potential without a significant amount of practice beforehand.
Additionally, Vayne also has some amount of utility and CC, a similar amount to Karma. This often makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Vayne vs Karma matchups, Vayne is the better champ with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your team members during teamfights.
Vayne is an above average counter for Karma. Focus your gameplay on keeping up your CS and destroying objectives. If you can do that, you should do very well as Vayne against Karma.
To truly master Vayne in order to counter Karma during both the laning and mid / late game phases of League of Legends, you should keep reading to gather a few extra tricks and insights into this matchup. If you pay attention to the build and stats presented above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Vayne usually picks up more CS relative to Karma. Champions who on average don't take much CS typically don't require much CS to be effective, such as supports. These kinds of champions are capable of scaling well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, usually require a lot of items to be effective. In either situation, try to do better than the values displayed here to do well.
The most important items to have in your Vayne versus Karma build consist of Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne combined at least these three pieces in her build, she performed a lot better when facing Karma than with many other commonly used item sets. In fact, Vayne had an average winrate of 52.7% when countering Karma with this counter build.
To have the best chance of beating Karma as Vayne, Vayne players should use the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune builds players used for Vayne vs Karma fights, this combination of runes yielded the highest win rate. Notably, these runes provided a 52.7% win rate overall.
By default, tips, statistics, and builds on how to beat Karma as Vayne are shown for all ranked divisions. If you want to narrow the statistics and builds to a specific rank, you can use the selection menu earlier on the page.