Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.
The stats provided here highlight several significant Vayne vs. Cassiopeia counter stats that can help you explain the differences and similarities between this pair of champs. As an example, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is more than Cassiopeia’s ratio of NaN, highlighting that Vayne may be more central to her team's team fighting capability than Cassiopeia..
Vayne typically has a similar longest killing spree as her enemy does. Typically, she receives less damage than Cassiopeia. This is usually reflective of different amounts of tankyness; however, it can also show that the champion with higher health has less mobility and thus is unable to escape additional harm when engaged or poked.
Both League champions are great. Both champs have their strengths, weaknesses, and counters. In League's current meta, Vayne usually loses when taking on Cassiopeia, with a 48.6% win rate. Therefore, Vayne makes a poor counter for Cassiopeia.
While Vayne does have a lower win rate compared to Cassiopeia, when they face off with one another, Vayne also has a lower learning curve that makes her a less complex character to develop with. You should be careful when picking Vayne into Cassiopeiaas her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Moreover, Vayne has some amount of utility and CC, a similar amount to Cassiopeia. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not one best champion for every situation in League of Legends, in Vayne vs Cassiopeia matchups, Cassiopeia is the better champ with a lower win rate, less champion complexity, and a similar amount of utility to help out your allies during team fights.
Vayne is a somewhat poor counter to Cassiopeia. Focus your play on keeping up your gold and cs and clearing objectives. If you do that, you should hold your own as Vayne against Cassiopeia.
To truly master Vayne in order to counter Cassiopeia during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you mind the build and tips presented here, you should grow your win rate by a lot and be closer to League of Legends pro players.
Vayne often racks up a similar amount of CS compared to Cassiopeia. Champs who typically don't earn much CS usualy don't need much CS to be effective, such as supports. These kinds of champions are able to scale properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically need several high cost items to be effective. In either case, try to surpass the values reported on this page to do well.
The ideal items to focus on in your Vayne versus Cassiopeia build include Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne included at least these three pieces in her build, she did significantly better when facing Cassiopeia than with most other typical counter builds. In fact, Vayne boasted an average win rate of 48.6% battling Cassiopeia with these items in her kit.
To have the greatest probability of crushing Cassiopeia as Vayne, Vayne players should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the runes players picked for Vayne vs Cassiopeia counter picks, this combo of runes resulted in the best win rate. Notably, these runes provided a 48.6% winrate overall.
By default, tips, statistics, and builds on how to beat Cassiopeia as Vayne are given for all skill levels combined. To scope the stats and builds to a particular player tier, you can use the selection menu earlier in the counter matchup guide.