Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons shown on this page clarify some important Twitch vs. Vayne matchup statistics that can help you grasp the distinctions between this pair of champs. For instance, Twitch’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vayne’s KDA ratio of NaN, showing that Twitch may be more central to his team's team fighting potential than Vayne..
Twitch typically has a similar longest kill spree as his enemy does. Commonly, he receives a similar amount of damage to Vayne. This commonly reflects differing health capacities, yet it can also indicate that the one champion has less agility and thus is not able to kite away from additional harm when poked or engaged.
Both LoL champions are great champions. Both have their pros and cons. In League's current meta, Twitch usually fairs equally well when trying to fight Vayne, with a 49.7% win rate. As a result, Twitch makes an ok counter to Vayne.
While Twitch does have a lower win rate than Vayne, when on opposite teams, Twitch also has a lower difficulty level that makes him a less difficult character to develop with. You should be careful when picking Twitch into Vayne.
Additionally, Twitch also has only a small amount of utility and CC, a similar amount to Vayne. This often makes her just as valuable during teamfights, especially when facing champions with a ton of burst damage.
While there is not one best champion overall in League of Legends, in Twitch vs Vayne matchups, Vayne is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your team members during team fights.
Twitch is a somewhat poor counter for Vayne. Make sure you focus your actions on increasing your CS and clearing objectives. If you can do that, you should be able to stand on your own as Twitch against Vayne.
To learn all of the intricacies of Twitch to counter Vayne during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra lessons on this matchup. If you listen to the build and suggestions shown above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Twitch often racks up a similar amount of CS compared to Vayne. Champs who on average don't earn many minion kills usualy don't have to have much CS to be effective, such as support champions. They are able to scale well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, usually need many items to be effective. In either case, try to exceed the numbers reported on this page to do well.
The ideal items to use in your Twitch versus Vayne build consist of Infinity Edge, Blade of The Ruined King, and Kraken Slayer. When Twitch used at least these three pieces in his build, he did much better when fighting Vayne than with many other commonly used counter builds. In fact, Twitch boasted an average winrate of 49.7% battling Vayne with this build.
To have the greatest chance of vanquishing Vayne as Twitch, Twitch players should equip the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Ultimate Hunter runes from the Precision and Domination rune sets. Of all the rune builds players used for Twitch vs Vayne face-offs, this mix of runes yielded the highest win rate. In fact, these runes gave a 49.7% win rate overall.
If you need to see Twitch x Vayne tips and builds for a an individual rank, feel free to select one from the selection menu provided above. By default, the stats and build suggestions displayed are calculated using all matches played with these champs.