Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The stat comparisons shown on this page clarify some important Twitch against Senna matchup stats that may help you realize the differences between the pair. Twitch’s KDA ratio ([kills + assists] / deaths) of NaN is better than Senna’s KDA ratio of NaN, demonstrating that Twitch may be more central to his team's team fighting effectiveness than Senna. This observation is in large part caused by the difference in kills.
Twitch normally has a much larger longest kill spree than his matchup does. On average, he receives a similar amount of damage to Senna. This often reflects differing health capacities; however, it can also show that the one champion has less agility and thus is not able to escape additional damage when poked or engaged.
Both LoL champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Twitch usually fairs equally well when taking on Senna, with a 49.0% win rate. Therefore, Twitch makes an ok counter for Senna.
While Twitch does have a lower winrate than Senna, when they face off with one another, Twitch also has a lower learning curve that makes him a less complex champion to develop with. You still need to be cautious when picking Twitch into Senna.
Furthermore, Twitch has almost no amount of utility and CC, a similar amount to Senna. This often makes her just as valuable during team fights, especially when fighting champions with a ton of burst damage.
While there isn't one best champion for every situation in League of Legends, in Twitch vs Senna matchups, Senna is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your teammates during team fights.
Twitch is a somewhat poor counter for Senna. Make sure you focus your actions on maximizing your CS and destroying objectives. If you can do that, you should do very well as Twitch against Senna.
To learn all of the intricacies of Twitch in order to counter Senna during both the early game and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you pay attention to the build and suggestions shown above, you will increase your win rate significantly and be closer to League of Legends pro players.
Twitch most often accumulates more CS compared to Senna. Champions who on average don't get much CS often don't require much CS to be effective, such as support champions. These kinds of champions are capable of scaling properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically require many items to be effective. In either situation, try to exceed the numbers reported here to do well.
The best items to prioritize in your Twitch versus Senna build consist of Guardian Angel, Blade of The Ruined King, and Terminus. When Twitch used at least these three items in his build, he performed significantly better vs. Senna than with most other commonly used counter builds. In fact, Twitch had an average winrate of 49.0% when playing against Senna with this build.
To have the highest probability of annihilating Senna as Twitch, you should take the Hail of Blades, Sudden Impact, Eyeball Collection, Relentless Hunter, Presence of Mind, and Legend: Alacrity runes from the Domination and Precision rune sets. Out of all the rune combinations players used for Twitch vs Senna face-offs, this order of runes yielded the highest win rate. Notably, these runes averaged a 49.0% winrate overall.
If you would like to see Twitch versus Senna tips and builds for a an individual division rank, feel free to choose one from the selection menu provided above. If viewing for the first time, the statistics and guides shown are computed using all matches with data with both champions.