Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons shown on this page clarify some influential Twitch vs. Karthus matchup statistics that may help you figure out the differences between this set of champs. Twitch’s KDA ratio ([kills + assists] / deaths) of NaN is more than Karthus’s ratio of NaN, demonstrating that Twitch may be more central to his team's team fighting effectiveness than Karthus..
Twitch often has a slightly larger longest kill spree than his enemy does. Typically, he receives less damage than Karthus. This commonly reflects different amounts of tankyness; however, it can also illustrate that the one champion has less mobility and thus is not able to flee from additional damage when engaged or poked.
Both League of Legends champs are great. Both have their pros and cons. In the game's current meta, Twitch usually wins when taking on Karthus, with a 53.5% win rate. As a result, Twitch makes a great counter for Karthus.
While Twitch does have a higher winrate than Karthus, when they face off with one another, Twitch also has a lower level of difficulty that makes him a less challenging character to develop with. You should be be fine when picking Twitch into Karthus.
Moreover, Twitch also has almost no amount of CC and other utility, a similar amount to Karthus. This often makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there is not one best champion overall in League of Legends, in Twitch vs Karthus matchups, Twitch is the better champion with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your allies during team fights.
Twitch is a great counter to Karthus. Make sure you focus your actions on increasing your gold income and taking out objectives. If you do that, you should do very well as Twitch against Karthus.
If you would like to learn all of the intricacies of Twitch to counter Karthus during both the laning and mid / late game phases of League of Legends, you should continue reading to gather a few extra tricks and insights into this matchup. If you listen to the build and tips displayed here, you should increase your win rate by a lot and be closer to League of Legends pro players.
Twitch usually gets more CS as Karthus. Champs who typically don't earn much CS usualy don't need much CS to be valuable teammates, such as support champions. They are able to scale well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually require several high cost items to be effective. In either case, try to do better than the numbers reported on this page to do well.
The most important items to focus on in your Twitch versus Karthus build include Experimental Hexplate, Runaan's Hurricane, and Blade of The Ruined King. When Twitch included at least these three items in his build, he did much better vs Karthus than with most other common builds. In fact, Twitch boasted an average winrate of 53.5% battling Karthus with this counter build.
To have the best chance of vanquishing Karthus as Twitch, Twitch players should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the rune combinations we have analyed for Twitch vs Karthus battles, this combination of runes yielded the greatest win rate. Notably, these runes provided a 53.5% winrate overall.
If you would like to view Twitch versus Karthus tips and counter stats for a a particular rank, feel free to choose one from the selection menu displayed above. If viewing for the first time, the stats and guides given are calculated using every game played with these champions.