Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Kai'Sa is very vulnerable to getting outranged by mages and long range carries.
Make sure to place wards in your blind spots so you can see Kai'Sa coming.
Kai'Sa is very good at picking off isolated enemies. Stick together against her.
The stats shown here clarify several significant Twitch versus Kai'Sa matchup statistics that may help us figure out the differences and similarities between the two. For instance, Twitch’s KDA ratio ([kills + assists] / deaths) of NaN is more than Kai'Sa’s KDA ratio of NaN, indicating that Twitch may be more central to his team's team fighting potential than Kai'Sa..
Twitch typically has a similar longest kill spree as his counter does. On average, he receives a similar amount of damage to Kai'Sa. This often reflects different amounts of tankyness, but it can also show that the one champion has less agility and thus is unable to escape additional harm when poked or engaged.
Both League champs are great. Both have their strengths, weaknesses, and counters. In League's current meta, Twitch usually wins when playing against Kai'Sa, with a 52.8% win rate. Therefore, Twitch makes a good counter for Kai'Sa.
While Twitch does have a higher win rate compared to Kai'Sa, when facing one another, Twitch also has a greater level of difficulty that makes him a more time consuming character to pick up and master. You should be be fine when picking Twitch into Kai'Sa.
Furthermore, Twitch also has almost no amount of CC and other utility, a similar amount to Kai'Sa. This often makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there is not a single best champion overall in League of Legends, in Twitch vs Kai'Sa matchups, Twitch is the better champ with a noticably higher win rate, similar champion depth, and a similar amount of utility to help out your teammates during team fights.
Twitch is an above average counter to Kai'Sa. You will do well by focussing your play on keeping up your CS and destroying objectives. If you do that, you should do very well as Twitch against Kai'Sa.
If you would like to learn all of the intricacies of Twitch to counter Kai'Sa during both the lane and mid / late game phases of League of Legends, you should continue reading to learn a few extra tricks and insights into this matchup. If you pay attention to the build and tips shown above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Twitch on average picks up a similar amount of CS relative to Kai'Sa. Champs who typically don't get many minion kills usualy don't need much CS to be valuable teammates, such as support champions. These kinds of champions are capable of scaling well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, typically need a lot of items to be effective. In either case, try to surpass the numbers displayed on this page to do well.
The best items to focus on in your Twitch versus Kai'Sa build include Nashor's Tooth, Zhonya's Hourglass, and Shadowflame. When Twitch used at least these three items in his build, he did a lot better when facing Kai'Sa than with most other typical counter builds. In fact, Twitch boasted an average winrate of 52.8% when playing against Kai'Sa with these items in his kit.
To have the best probability of annihilating Kai'Sa as Twitch, you should take the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Ultimate Hunter runes from the Precision and Domination rune sets. Out of all the rune builds players picked for Twitch vs Kai'Sa matchups, this order of runes yielded the greatest win rate. Notably, these runes provided a 52.8% winrate overall.
By default, tips, statistics, and builds on how to beat Kai'Sa as Twitch are displayed for all ranked divisions combined. If you want to scope the statistics and builds to a distinct player tier, you can use the selection menu located earlier on the page.