Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.
The stats provided here emphasize some influential Twitch versus Cassiopeia matchup stats that can help you explain the differences between this set of champs. As an example, Twitch’s KDA ratio ([kills + assists] / deaths) of NaN is more than Cassiopeia’s ratio of NaN, indicating that Twitch may be more central to his team's team fighting capability than Cassiopeia..
Twitch often has a slightly larger longest killing spree than his enemy does. Typically, he takes less damage than Cassiopeia. This is usually reflective of differing health capacities, yet it can also hint that the champion with increased HP has less mobility and thus is unable to escape further damage when engaged or poked.
Both League of Legends champions are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Twitch usually fairs equally well when playing against Cassiopeia, with a 49.2% win rate. Therefore, Twitch makes an ok counter to Cassiopeia.
While Twitch does have a lower winrate than Cassiopeia, when on opposite teams, Twitch also has a much lower learning curve that makes him a less challenging character to pick up and master. You should be careful when picking Twitch into Cassiopeia.
Furthermore, Twitch also has almost no amount of CC and other utility, a similar amount to Cassiopeia. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't one best champion in League of Legends, in Twitch vs Cassiopeia matchups, Cassiopeia is the better champ with a similar win rate, less champion complexity, and a similar amount of utility to help out your allies during late stage team fights.
Twitch is a somewhat poor counter for Cassiopeia. You will do well by focussing your actions on increasing your gold and cs and clearing objectives. If you are able to do that, you should do very well as Twitch against Cassiopeia.
To learn all of the intricacies of Twitch to counter Cassiopeia during both the lane and mid / late game phases of League of Legends, you should keep reading to gather a few extra tips and tricks for this matchup. If you listen to the build and stats presented here, you should increase your win rate significantly and be that much closer to League of Legends pro players.
Twitch most often gets a similar amount of CS relative to Cassiopeia. Champions who on average don't take many minion kills typically don't require much CS to be effective, such as supports. They are capable of scaling properly off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically require a lot of items to be effective. In either situation, try to surpass the numbers shown on this page to do well.
The ideal items to focus on in your Twitch versus Cassiopeia build include Wit's End, Blade of The Ruined King, and Terminus. When Twitch included at least these three items in his build, he did a lot better vs. Cassiopeia than with most other commonly used item sets. In fact, Twitch boasted an average win rate of 49.2% battling Cassiopeia with this build.
To have the highest probability of coming out on top against Cassiopeia as Twitch, you should take the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the rune sets players picked for Twitch vs Cassiopeia clashes, this set of runes resulted in the best win rate. Notably, these runes averaged a 49.2% win rate overall.
By default, tips, stats, and builds on how to beat Cassiopeia as Twitch are given for all ranked divisions combined. To narrow the statistics and builds to a particular division, you should use the selection menu earlier on the page.