Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
The stat comparisons shown here feature some critical Sett versus Vladimir counter stats that may help us explain the distinctions between the two. As an example, Sett’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vladimir’s ratio of NaN, highlighting that Sett may be more central to his team's team fighting effectiveness than Vladimir..
Sett normally has a similar longest killing spree as his foe does. Typically, he receives a similar amount of damage to Vladimir. This often reflects different amounts of tankyness; however, it can also hint that the one champ has less mobility and thus is unable to flee from further damage when engaged or poked.
Both League of Legends champs are great. Both have their pros and cons. In the game's current meta, Sett usually fairs equally well when playing against Vladimir, with a 50.3% win rate. As a result, Sett makes an ok counter to Vladimir.
While Sett does have a higher win rate than Vladimir, when facing one another, Sett also has a much lower level of difficulty that makes him a less complex champ to learn. You should be careful when picking Sett into Vladimir.
Additionally, Sett also has almost no amount of CC and other utility, a similar amount to Vladimir. This often makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there isn't a single best champion overall in League of Legends, in Sett vs Vladimir matchups, Sett is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Sett is a decent counter to Vladimir. Make sure you focus your tactics on keeping up your CS and taking out objectives. If you are able to do that, you should be able to stand on your own as Sett against Vladimir.
If you would like to learn all of the intricacies of Sett to counter Vladimir during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tips and tricks for this matchup. If you listen to the build and tips presented here, you will increase your win rate significantly and be that much closer to League of Legends pro players.
Sett most often accumulates a similar amount of CS as Vladimir. Champs who typically don't earn much CS usualy don't need much CS to be valuable teammates, such as support champions. They are able to scale properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often require several high cost items to be effective. In either situation, try to exceed the numbers reported on this page to do well.
The most important items to prioritize in your Sett versus Vladimir build consist of Black Cleaver, Sundered Sky, and Stridebreaker. When Sett combined at least these three items in his build, he performed much better versus Vladimir than with many other commonly used item sets. In fact, Sett had an average winrate of 50.3% when playing against Vladimir with these items in his kit.
To have the best likelihood of annihilating Vladimir as Sett, Sett players should equip the Grasp of the Undying, Demolish, Second Wind, Overgrowth, Last Stand, and Triumph runes from the Resolve and Precision rune sets. Of all the rune combinations players picked for Sett vs Vladimir counterpicks, this set of runes resulted in the best win rate. Moreover, these runes averaged a 50.3% win rate overall.
By default, tips, statistics, and builds on how to beat Vladimir as Sett are displayed for all skill levels combined. If you would like to scope the statistics and builds to a distinct skill level, you can use the selection menu located earlier in the counter matchup guide.