Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons shown on this page underscore some important Sett vs. Karthus matchup stats that can help us figure out the differences between this set of champions. For instance, Sett’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s ratio of NaN, highlighting that Sett may be more central to his team's team fighting effectiveness than Karthus..
Sett normally has a similar longest kill spree as his foe does. Typically, he receives more damage than Karthus. This typically indicates different amounts of tankyness, yet it can also indicate that the one champion has less mobility and thus is unable to escape further harm when poked or engaged.
Both League champions are great. Both have their strengths, weaknesses, and counters. In League's current meta, Sett usually wins when playing against Karthus, with a 53.1% win rate. Thus, Sett makes a great counter to Karthus.
While Sett does have a higher win rate than Karthus, when on opposite teams, Sett also has a much lower difficulty level that makes him a less challenging champ to learn. You should be be fine when picking Sett into Karthus.
Moreover, Sett also has only a small amount of utility and CC, a similar amount to Karthus. This often makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there is not one best champion overall in League of Legends, in Sett vs Karthus matchups, Sett is the better champ with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Sett is a great counter for Karthus. Focus your gameplay on increasing your gold and cs and destroying objectives. If you can do that, you should hold your own as Sett against Karthus.
To learn all of the intricacies of Sett to counter Karthus during both the early game and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you mind the build and tips presented here, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Sett on average gets more CS relative to Karthus. Champs who typically don't acquire many minion kills usualy don't require much CS to be effective, such as support champions. They are capable of scaling properly off of their abilities and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, often require several high cost items to be effective. In either situation, try to exceed the numbers displayed on this page to do well.
The top items to prioritize in your Sett versus Karthus build consist of Sterak's Gage, Titanic Hydra, and Sundered Sky. When Sett included at least these three pieces in his build, he performed a lot better against Karthus than with many other commonly used builds. In fact, Sett had an average winrate of 53.1% when playing against Karthus with this build.
To have the highest likelihood of crushing Karthus as Sett, Sett players should use the Conqueror, Triumph, Legend: Alacrity, Last Stand, Second Wind, and Unflinching runes from the Precision and Resolve rune sets. Of all the rune sets players chose for Sett vs Karthus face-offs, this blending of runes yielded the highest win rate. In fact, these runes gave a 53.1% win rate overall.
If you need to see Sett versus Karthus tips and counter stats for a a particular skill level, feel free to choose one from the selection menu displayed above. At first, the statistics and guides displayed are calculated using all matches run with both champs.