Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown here show several significant Seraphine versus Vayne counter stats that may help you understand the differences and similarities between the two. As an example, Seraphine’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s ratio of NaN, highlighting that Seraphine may be more central to her team's team fighting capacity than Vayne. This observation is largely fueled by the differences in assists.
Seraphine often has a significantly smaller longest kill spree than her matchup does. Typically, she receives less damage than Vayne. This is usually reflective of different amounts of tankyness; however, it can also indicate that the champ with increased health has less agility and thus is not able to escape additional harm when poked or engaged.
Both League of Legends champs are great. Both have their strengths, weaknesses, and counters. In League's current meta, Seraphine usually fairs equally well when facing off against Vayne, with a 49.3% win rate. As a result, Seraphine makes an ok counter to Vayne.
While Seraphine does have a lower winrate than Vayne, when facing one another, Seraphine also has a much lower learning curve that makes her a less difficult character to develop with. You still need to be cautious when picking Seraphine into Vayne.
Furthermore, Seraphine also has a great amount of utility and CC, a similar amount to Vayne. This often makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there is not a single best champion overall in League of Legends, in Seraphine vs Vayne matchups, Vayne is the better champ with a similar win rate, less champion complexity, and a similar amount of utility to help out your allies during late stage team fights.
Seraphine is a somewhat poor counter to Vayne. You will do well by focussing your play on keeping up your CS and taking out objectives. If you can do that, you should do very well as Seraphine against Vayne.
If you would like to truly master Seraphine to counter Vayne during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tips and tricks for this matchup. If you pay attention to the build and stats shown here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Seraphine usually accumulates less CS as Vayne. Champions who typically don't take much CS often don't require much CS to be valuable teammates, such as supports. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually require many items to be effective. In either situation, try to surpass the values shown on this page to do well.
The most crucial items to have in your Seraphine versus Vayne build consist of Seraph's Embrace, Zaz'Zak's Realmspike, and Liandry's Torment. When Seraphine used at least these three items in her build, she did significantly better versus Vayne than with most other commonly used item sets. In fact, Seraphine had an average win rate of 49.3% when playing against Vayne with this counter build.
To have the highest probability of vanquishing Vayne as Seraphine, you should use the Summon Aery, Manaflow Band, Transcendence, Gathering Storm, Presence of Mind, and Coup de Grace runes from the Sorcery and Precision rune sets. Of all the rune builds players used for Seraphine vs Vayne counterpicks, this mix of runes yielded the best win rate. Moreover, these runes averaged a 49.3% winrate overall.
If you want to view Seraphine x Vayne tips and matchup stats and build suggestions for a a specific rank, feel free to choose one from the selection menu above. By default, the stats and build suggestions shown are computed using every game completed with both champs.