Zilean is fragile if a team focuses on him, but otherwise he's very difficult to kill. Commit to killing him as a team.
If you're able to match Zilean's speed, it can sometimes be beneficial to wait until his ultimate has faded before landing the killing blow.
The stat comparisons shown here highlight several significant Senna vs. Zilean counter stats that can help us grasp the differences between the pair. Senna’s KDA ratio ([kills + assists] / deaths) of NaN is more than Zilean’s KDA ratio of NaN, demonstrating that Senna may be more central to her team's team fighting potential than Zilean..
Senna usually has a slightly larger longest killing spree than her opponent does. Typically, she receives a similar amount of damage to Zilean. This typically indicates differing health capacities, but it can also illustrate that the one champ has less mobility and thus is unable to flee from further harm when poked or engaged.
Both League champs are great. Both have their pros and cons. In League's current meta, Senna usually fairs equally well when facing off against Zilean, with a 49.9% win rate. Therefore, Senna makes an ok counter for Zilean.
While Senna does have a lower win rate than Zilean, when facing one another, Senna also has a greater learning curve that makes her a more challenging champ to pick up and master. You should be careful when picking Senna into Zileanas her relative depth means that you may not be able to unleash her full potential without a significant amount of practice beforehand.
Additionally, Senna has a good amount of CC and other utility, a similar amount to Zilean. This often makes her just as valuable during team fights, especially when facing champions with a lot of burst damage.
While there isn't one best champion overall in League of Legends, in Senna vs Zilean matchups, Zilean is the better champ with a similar win rate, more champion depth, and a similar amount of utility to help out your team members during team fights.
Senna is a somewhat poor counter for Zilean. Focus your gameplay on keeping up your CS and taking out objectives. If you do that, you should do very well as Senna against Zilean.
If you would like to truly master Senna to counter Zilean during both the lane and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you mind the build and suggestions displayed above, you should increase your win rate by a lot and be closer to League of Legends pro players.
Senna on average picks up a similar amount of CS as Zilean. Champions who typically don't earn much CS typically don't need much CS to be valuable teammates, such as support champions. These kinds of champions are able to scale properly off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often have to have many items to be effective. In either situation, try to do better than the values reported here to do well.
The top items to use in your Senna versus Zilean build consist of Bloodsong, The Collector, and Voltaic Cyclosword. When Senna combined at least these three items in her build, she performed significantly better countering Zilean than with most other typical counter builds. In fact, Senna had an average win rate of 49.9% when playing against Zilean with these items in her kit.
To have the highest probability of defeating Zilean as Senna, Senna players should use the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Bone Plating, and Revitalize runes from the Precision and Resolve rune sets. Of all the runes players picked for Senna vs Zilean LoL games, this composite of runes yielded the highest win rate. Notably, these runes gave a 49.9% win rate overall.
If you want to see Senna x Zilean tips and builds for a a specific division rank, feel free to select one from the selection menu displayed above. At first, the stats and guides shown are calculated using all matches run with these champs.