Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
The stats shown on this page clarify several valuable Senna against Vladimir matchup stats that can help us interpret the distinctions between the two. For instance, Senna’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vladimir’s ratio of NaN, demonstrating that Senna may be more central to her team's team fighting effectiveness than Vladimir. This observation is largely fueled by the differences in assists.
Senna often has a similar longest killing spree as her foe does. Typically, she takes less damage than Vladimir. This is usually reflective of different amounts of tankyness, yet it can also imply that the one champ has less agility and thus is unable to kite away from further harm when engaged or poked.
Both LoL champs are great champions. Both champs have their pros and cons. In League's current meta, Senna usually wins when facing off against Vladimir, with a 52.4% win rate. As a result, Senna makes a good counter for Vladimir.
While Senna does have a higher win rate compared to Vladimir, when facing one another, Senna also has a greater level of difficulty that makes her a more time consuming champion to learn and master. You don't need to be too worried when picking Senna into Vladimiras her relative depth means that you may not be able to reach her full potential without a lot of practice beforehand.
Moreover, Senna has a good amount of utility and CC, a similar amount to Vladimir. This often makes her just as valuable during team fights, especially when fighting champions with a ton of burst damage.
While there is not a single best champion for every situation in League of Legends, in Senna vs Vladimir matchups, Senna is the better champ with a noticably higher win rate, similar champion depth, and a similar amount of utility to help out your team members during team fights.
Senna is an above average counter to Vladimir. Focus your tactics on keeping up your CS and taking out objectives. If you are able to do that, you should be able to stand on your own as Senna against Vladimir.
If you would like to learn all of the intricacies of Senna to counter Vladimir during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you mind the build and tips shown above, you should increase your win rate by a lot and be that much closer to League of Legends pro players.
Senna often accumulates less CS compared to Vladimir. Champs who on average don't acquire many minion kills typically don't have to have much CS to be effective, such as supports. These kinds of champions are able to scale properly off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically need several high cost items to be effective. In either situation, try to exceed the numbers reported here to do well.
The most important items to use in your Senna versus Vladimir build consist of Infinity Edge, Umbral Glaive, and Bloodsong. When Senna used at least these three items in her build, she did a lot better against Vladimir than with most other typical item sets. In fact, Senna boasted an average win rate of 52.4% when countering Vladimir with this build.
To have the best chance of defeating Vladimir as Senna, you should equip the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Biscuit Delivery, and Approach Velocity runes from the Precision and Inspiration rune sets. Of all the rune sets players picked for Senna vs Vladimir battles, this order of runes yielded the greatest win rate. In fact, these runes provided a 52.4% win rate overall.
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