Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats provided here show some valuable Senna against Vayne counter statistics that may help us realize the distinctions between the pair. Senna’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s KDA ratio of NaN, demonstrating that Senna may be more central to her team's team fighting capability than Vayne. This observation is in large part a result of the differences in assists.
Senna typically has a slightly smaller longest killing spree than her opponent does. Commonly, she receives less damage than Vayne. This commonly reflects differing health capacities, yet it can also imply that the champ with increased health has less mobility and thus is unable to flee from further damage when poked or engaged.
Both League of Legends champs are great champions. Both have their pros and cons. In the game's current meta, Senna usually wins when taking on Vayne, with a 51.9% win rate. Therefore, Senna makes a good counter for Vayne.
While Senna does have a higher win rate than Vayne, when they face off with one another, Senna also has a lower difficulty level that makes her a less difficult champ to learn and master. You still need to be cautious when picking Senna into Vayneas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Moreover, Senna has a good amount of CC and other utility, a similar amount to Vayne. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there is not one best champion in League of Legends, in Senna vs Vayne matchups, Senna is the better champ with a higher win rate, less champion complexity, and a similar amount of utility to help out your allies during late stage team fights.
Senna is a decent counter for Vayne. You will do well by focussing your strategy on maximizing your gold income and destroying objectives. If you are able to do that, you should be able to stand on your own as Senna against Vayne.
To learn all of the intricacies of Senna to counter Vayne during both the lane and mid / late game phases of League of Legends, you should keep reading to learn a few extra tricks and insights into this matchup. If you listen to the build and suggestions presented above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Senna most often gets less CS as Vayne. Champs who typically don't take much CS often don't have to have much CS to be effective, such as sup champs. They are capable of scaling well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, usually need several high cost items to be effective. In either case, try to do better than the values shown on this page to do well.
The ideal items to use in your Senna versus Vayne build consist of Rapid Firecannon, The Collector, and Serylda's Grudge. When Senna included at least these three pieces in her build, she did a lot better when facing Vayne than with most other typical counter builds. In fact, Senna boasted an average winrate of 51.9% when countering Vayne with this build.
To have the greatest probability of crushing Vayne as Senna, you should take the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Bone Plating, and Revitalize runes from the Precision and Resolve rune sets. Of all the rune sets we have analyed for Senna vs Vayne battles, this composite of runes resulted in the best win rate. Notably, these runes provided a 51.9% win rate overall.
By default, tips, stats, and builds on how to beat Vayne as Senna are shown for all ranked divisions. If you want to narrow the statistics and builds to a distinct rank, you may use the selection menu earlier in the counter matchup guide.