Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown on this page underscore several critical Samira versus Vayne matchup stats that can help you figure out the differences between the pair. Samira’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vayne’s KDA ratio of NaN, showing that Samira may be more central to her team's team fighting capability than Vayne..
Samira typically has a slightly larger longest killing spree than her matchup does. Typically, she takes a similar amount of damage to Vayne. This typically indicates differing health capacities; however, it can also hint that the one champ has less agility and thus is not able to flee from further harm when engaged or poked.
Both League champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Samira usually loses when playing against Vayne, with a 48.3% win rate. As a result, Samira makes a bad counter for Vayne.
While Samira does have a lower win rate compared to Vayne, when they face off with one another, Samira also has a lower learning curve that makes her a less complex character to pick up and master. You still need to be cautious when picking Samira into Vayne.
Furthermore, Samira also has almost no amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during team fights, especially when facing champions with a ton of burst damage.
While there isn't a single best champion for every situation in League of Legends, in Samira vs Vayne matchups, Vayne is the better champion with a lower win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Samira is a somewhat poor counter to Vayne. Focus your strategy on increasing your gold income and destroying objectives. If you do that, you should do very well as Samira against Vayne.
If you would like to learn all of the intricacies of Samira to counter Vayne during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tricks and insights into this matchup. If you pay attention to the build and stats presented above, you will increase your win rate by a lot and be that much closer to League of Legends pro players.
Samira most often gets a similar amount of CS relative to Vayne. Champs who on average don't take many minion kills often don't need much CS to be effective, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically need a lot of items to be effective. In either case, try to do better than the numbers shown on this page to do well.
The most important items to use in your Samira versus Vayne build include Infinity Edge, Bloodthirster, and Hubris. When Samira used at least these three pieces in her build, she did significantly better vs Vayne than with many other typical counter builds. In fact, Samira had an average winrate of 48.3% when playing against Vayne with this counter build.
To have the highest probability of defeating Vayne as Samira, Samira players should equip the Conqueror, Triumph, Legend: Bloodline, Last Stand, Eyeball Collection, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune builds players chose for Samira vs Vayne battles, this blending of runes resulted in the best win rate. Moreover, these runes averaged a 48.3% winrate overall.
If you would like to view Samira x Vayne tips and matchup stats and build suggestions for a a particular rank, feel free to choose one from the selection menu shown above. At first, the stats and guides given are computed using every match completed with these champions.