You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stats shown on this page clarify some influential Neeko versus Vayne counter statistics that may help you appreciate the differences between the pair. Neeko’s KDA ratio ([kills + assists] / deaths) of NaN is better than Vayne’s KDA ratio of NaN, indicating that Neeko may be more central to her team's team fighting effectiveness than Vayne..
Neeko normally has a slightly smaller longest killing spree than her matchup does. On average, she takes a similar amount of damage to Vayne. This often reflects different amounts of tankyness, but it can also show that the champ with more health has less agility and thus is not able to flee from further harm when engaged or poked.
Both LoL champions are great champions. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Neeko usually fairs equally well when facing off against Vayne, with a 50.4% win rate. Thus, Neeko makes an ok counter for Vayne.
While Neeko does have a higher winrate compared to Vayne, when facing one another, Neeko also has a lower level of difficulty that makes her a less difficult champion to develop with. You should be careful when picking Neeko into Vayne.
Moreover, Neeko has some amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during teamfights, especially when fighting champions with a ton of burst damage.
While there isn't one best champion for every situation in League of Legends, in Neeko vs Vayne matchups, Neeko is the better champ with a similar win rate, less champion complexity, and a similar amount of utility to help out your allies during teamfights.
Neeko is a decent counter to Vayne. You will do well by focussing your play on increasing your gold and cs and clearing objectives. If you can do that, you should be able to stand on your own as Neeko against Vayne.
To truly master Neeko in order to counter Vayne during both the lane and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you mind the build and stats displayed above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Neeko typically accumulates a similar amount of CS as Vayne. Champions who on average don't acquire many minion kills often don't have to have much CS to be valuable teammates, such as support champions. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually have to have many items to be effective. In either case, try to surpass the numbers displayed here to do well.
The best items to use in your Neeko versus Vayne build include Hextech Rocketbelt, Zhonya's Hourglass, and Zaz'Zak's Realmspike. When Neeko used at least these three pieces in her build, she performed much better when facing Vayne than with many other commonly used builds. In fact, Neeko had an average win rate of 50.4% when countering Vayne with this build.
To have the greatest chance of annihilating Vayne as Neeko, Neeko players should take the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the rune sets that we analyzed for Neeko vs Vayne battles, this sequence of runes yielded the greatest win rate. Moreover, these runes averaged a 50.4% win rate overall.
By default, tips, stats, and builds on how to beat Vayne as Neeko are shown for all ranked divisions combined. To filter the stats and builds to a specific player tier, you can use the selection menu at the top of this page.