While ganking, consider aiming Dredge Line at nearby terrain and following it up with Riptide for a higher hit rate.
Riptide has a delayed blast timing on activation - you can use this while running away or when enemies are incoming to serve as a deterrent.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons provided here underscore some valuable Nautilus against Vayne counter stats that may help you understand the differences between the two. For instance, Nautilus’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Vayne’s ratio of NaN, highlighting that Nautilus may be more central to his team's team fighting potential than Vayne. This observation is in large part a result of the differences in assists.
Nautilus usually has a significantly smaller longest killing spree than his opponent does. On average, he receives a similar amount of damage to Vayne. This often reflects different amounts of tankyness, but it can also illustrate that the one champion has less agility and thus is not able to flee from further damage when poked or engaged.
Both League champions are great. Both have their pros and cons. In League's current meta, Nautilus usually fairs equally well when facing off against Vayne, with a 50.1% win rate. Thus, Nautilus makes an ok counter to Vayne.
While Nautilus does have a higher win rate than Vayne, when facing one another, Nautilus also has a lower level of difficulty that makes him a less challenging champ to learn and master. You should be careful when picking Nautilus into Vayne.
Furthermore, Nautilus has a good amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Nautilus vs Vayne matchups, Nautilus is the better champ with a similar win rate, less champion complexity, and a similar amount of utility to help out your teammates during teamfights.
Nautilus is a decent counter to Vayne. Make sure you focus your gameplay on increasing your CS and clearing objectives. If you do that, you should hold your own as Nautilus against Vayne.
If you would like to truly master Nautilus in order to counter Vayne during both the laning and mid / late game phases of League of Legends, you should keep reading to pick up a few extra lessons on this matchup. If you mind the build and suggestions presented here, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Nautilus usually picks up a lot less CS as Vayne. Champs who typically don't take much CS usualy don't require much CS to be effective, such as supports. They are capable of scaling properly off of their skills, stats, and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually need a lot of items to be effective. In either situation, try to surpass the values displayed on this page to do well.
The top items to prioritize in your Nautilus versus Vayne build include Zeke's Convergence, Thornmail, and Frozen Heart. When Nautilus bought at least these three pieces in his build, he performed a lot better countering Vayne than with most other commonly used counter builds. In fact, Nautilus had an average win rate of 50.1% battling Vayne with these items in his kit.
To have the best likelihood of coming out on top against Vayne as Nautilus, you should use the Aftershock, Shield Bash, Conditioning, Revitalize, Legend: Tenacity, and Triumph runes from the Resolve and Precision rune sets. Of all the runes players used for Nautilus vs Vayne face-offs, this set of runes resulted in the best win rate. In fact, these runes gave a 50.1% win rate overall.
If you want to view Nautilus versus Vayne tips and matchup stats and build suggestions for a a distinct skill level, feel free to choose one from the selection menu above. At first, the stats and strategies displayed are calculated using every match run with both champions.