Miss Fortune ramps up speed if she hasn't recently taken damage. Avoid getting hit to move very fast.
Use Double Up on the furthest enemy minion if enemy champions are hiding in back; it will bounce to them for lots of damage.
Make sure to utilize Love Tap while Strut is on cooldown to maximize the active's availability.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons shown on this page emphasize some vital Miss Fortune versus Vayne counter stats that may help you explain the distinctions between the pair. Miss Fortune’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s ratio of NaN, indicating that Miss Fortune may be more central to her team's team fighting effectiveness than Vayne..
Miss Fortune normally has a slightly larger longest kill spree than her opponent does. On average, she takes a similar amount of damage to Vayne. This often reflects different amounts of tankyness; however, it can also hint that the one champ has less mobility and thus is not able to kite away from further harm when engaged or poked.
Both LoL champs are great. Both have their pros and cons. In League's current meta, Miss Fortune usually wins when trying to fight Vayne, with a 54.4% win rate. Therefore, Miss Fortune makes a great counter to Vayne.
While Miss Fortune does have a much higher winrate than Vayne, when on opposite teams, Miss Fortune also has a much lower difficulty level that makes her a less challenging champion to pick up and master. You should be be fine when picking Miss Fortune into Vayne.
Moreover, Miss Fortune also has almost no amount of utility and CC, a similar amount to Vayne. This often makes her just as valuable during team fights, especially when facing champions with a lot of burst damage.
While there is not one best champion overall in League of Legends, in Miss Fortune vs Vayne matchups, Miss Fortune is the better champ with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Miss Fortune is a great counter to Vayne. You will do well by focussing your gameplay on increasing your gold income and clearing objectives. If you can do that, you should do very well as Miss Fortune against Vayne.
If you would like to learn all of the intricacies of Miss Fortune in order to counter Vayne during both the early game and mid / late game phases of League of Legends, you should continue reading to learn a few extra tricks and insights into this matchup. If you listen to the build and tips shown above, you should increase your win rate significantly and be closer to League of Legends pro players.
Miss Fortune often picks up a similar amount of CS as Vayne. Champs who on average don't acquire many minion kills usualy don't need much CS to be valuable teammates, such as sup champs. They are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, usually have to have several high cost items to be effective. In either situation, try to do better than the numbers shown here to do well.
The top items to prioritize in your Miss Fortune versus Vayne build include Rapid Firecannon, Youmuu's Ghostblade, and Hubris. When Miss Fortune incorporated at least these three pieces in her build, she did significantly better countering Vayne than with many other commonly used counter builds. In fact, Miss Fortune boasted an average winrate of 54.4% battling Vayne with this build.
To have the greatest probability of beating Vayne as Miss Fortune, you should equip the First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight, Gathering Storm, and Manaflow Band runes from the Inspiration and Sorcery rune sets. Of all the rune builds players used for Miss Fortune vs Vayne fights, this combo of runes resulted in the highest win rate. Notably, these runes averaged a 54.4% winrate overall.
If you would like to get Miss Fortune vs Vayne tips and builds for a a distinct skill level, feel free to choose one from the selection menu above. If viewing for the first time, the statistics and build suggestions displayed are computed using all matches finished with both champs.