Miss Fortune ramps up speed if she hasn't recently taken damage. Avoid getting hit to move very fast.
Use Double Up on the furthest enemy minion if enemy champions are hiding in back; it will bounce to them for lots of damage.
Make sure to utilize Love Tap while Strut is on cooldown to maximize the active's availability.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stats shown on this page feature some critical Miss Fortune vs. Karthus matchup stats that may help us appreciate the differences between these two champs. As an example, Miss Fortune’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s KDA ratio of NaN, showing that Miss Fortune may be more central to her team's team fighting capability than Karthus..
Miss Fortune often has a slightly larger longest kill spree than her enemy does. Typically, she takes less damage than Karthus. This often reflects differing health capacities, but it can also illustrate that the champion with increased HP has less mobility and thus is unable to kite away from further damage when engaged or poked.
Both League of Legends champs are great. Both have their pros and cons. In League's current meta, Miss Fortune usually wins when facing off against Karthus, with a 56.2% win rate. Therefore, Miss Fortune makes a fantastic counter for Karthus.
While Miss Fortune does have a much higher winrate than Karthus, when they face off with one another, Miss Fortune also has a much lower level of difficulty that makes her a less difficult character to learn and master. You should be be fine when picking Miss Fortune into Karthus.
Furthermore, Miss Fortune has almost no amount of CC and other utility, a similar amount to Karthus. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there is not a single best champion overall in League of Legends, in Miss Fortune vs Karthus matchups, Miss Fortune is the better champion with a noticably higher win rate, less champion complexity, and a similar amount of utility to help out your team members during late stage team fights.
Miss Fortune is a great counter for Karthus. You will do well by focussing your actions on increasing your CS and taking out objectives. If you do that, you should do very well as Miss Fortune against Karthus.
To truly master Miss Fortune to counter Karthus during both the early game and mid / late game phases of League of Legends, you should keep reading to gather a few extra tips and tricks for this matchup. If you pay attention to the build and stats presented here, you should grow your win rate significantly and be closer to League of Legends pro players.
Miss Fortune often picks up more CS relative to Karthus. Champions who typically don't acquire much CS typically don't require much CS to be valuable teammates, such as support champions. These kinds of champions are able to scale well off of their abilities and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either situation, try to surpass the values displayed here to do well.
The most important items to use in your Miss Fortune versus Karthus build consist of The Collector, Serylda's Grudge, and Hubris. When Miss Fortune bought at least these three pieces in her build, she did a lot better vs. Karthus than with most other commonly used builds. In fact, Miss Fortune boasted an average win rate of 56.2% when playing against Karthus with this counter build.
To have the highest chance of vanquishing Karthus as Miss Fortune, Miss Fortune players should use the First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight, Absolute Focus, and Gathering Storm runes from the Inspiration and Sorcery rune sets. Out of all the rune sets players chose for Miss Fortune vs Karthus clashes, this mix of runes yielded the greatest win rate. In fact, these runes provided a 56.2% win rate overall.
By default, tips, stats, and builds on how to beat Karthus as Miss Fortune are displayed for all skill levels, merged. If you want to narrow the statistics and builds to a particular skill level, you should use the selection menu at the top of this page.