Glitterlance can be fired at odd angles depending on where your cursor is - Moving your cursor closer to Pix and Lulu will change your area of effect size considerably.
Consider casting Help, Pix! on ranged attackers for the Pix boost and Wild Growth on Tanks or Fighters for the added initiation power.
Deny Vayne the opportunity to pin you against walls.
Vayne is fragile - turn the pressure up on her and she will be forced to play cautiously.
The stat comparisons provided here emphasize some important Lulu versus Vayne matchup statistics that can help you realize the differences between this set of champions. As an example, Lulu’s KDA ratio ([kills + assists] / deaths) of NaN is more than Vayne’s KDA ratio of NaN, demonstrating that Lulu may be more central to her team's team fighting effectiveness than Vayne. This observation is in large part a result of the differences in assists.
Lulu normally has a significantly smaller longest killing spree than her matchup does. On average, she receives less damage than Vayne. This is usually reflective of differing health capacities, but it can also indicate that the champion with more health has less mobility and thus is unable to escape additional harm when engaged or poked.
Both League of Legends champions are great. Both have their pros and cons. In League's current meta, Lulu usually loses when trying to fight Vayne, with a 47.5% win rate. Therefore, Lulu makes a poor counter for Vayne.
While Lulu does have a lower win rate compared to Vayne, when on opposite teams, Lulu also has a lower difficulty level that makes her a less challenging champion to pick up and master. You may get destroyed when picking Lulu into Vayne.
Additionally, Lulu has a good amount of utility and CC, a similar amount to Vayne. This makes her just as valuable during team fights, especially when fighting champions with a lot of burst damage.
While there is not one best champion in League of Legends, in Lulu vs Vayne matchups, Vayne is the better champ with a lower win rate, less champion complexity, and a similar amount of utility to help out your allied champions during team fights.
Lulu is a bad counter for Vayne. You will do well by focussing your play on keeping up your gold and cs and destroying objectives. If you do that, you should be able to stand on your own as Lulu against Vayne.
If you would like to truly master Lulu to counter Vayne during both the early game and mid / late game phases of League of Legends, you should continue reading to learn a few extra lessons on this matchup. If you pay attention to the build and suggestions shown above, you will grow your win rate by a lot and be that much closer to League of Legends pro players.
Lulu typically accumulates a lot less CS as Vayne. Champs who on average don't get many minion kills usualy don't require much CS to be effective, such as supports. These kinds of champions are able to scale properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, often have to have several high cost items to be effective. In either situation, try to surpass the numbers displayed here to do well.
The most crucial items to use in your Lulu versus Vayne build include Shurelya's Battlesong, Mikael's Blessing, and Ardent Censer. When Lulu bought at least these three pieces in her build, she did much better vs. Vayne than with most other common item sets. In fact, Lulu had an average winrate of 47.5% when playing against Vayne with these items in her kit.
To have the greatest likelihood of coming out on top against Vayne as Lulu, you should equip the Summon Aery, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the rune builds players picked for Lulu vs Vayne clashes, this order of runes resulted in the highest win rate. In fact, these runes gave a 47.5% win rate overall.
By default, tips, statistics, and builds on how to beat Vayne as Lulu are given for all ranked divisions combined. To scope the statistics and builds to a specific skill level, you should use the selection menu located earlier in the counter matchup guide.