Lissandra's abilities are shorter range than those of many mages. As a result, buying items that offer both ability power and defense, like Zhonya's Hourglass and Banshee's Veil, can be a great choice to help her both survive and deal damage.
Casting Glacial Path and then running in the opposite direction will leave your enemies uncertain which way you will actually go.
You can instantly use your ultimate on yourself by pressing the self cast key and the ultimate key at once (alt+R by default).
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons provided here clarify several important Lissandra vs. Karthus counter statistics that may help us distinguish the differences between the pair. For instance, Lissandra’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s ratio of NaN, indicating that Lissandra may be more central to her team's team fighting capacity than Karthus..
Lissandra usually has a slightly smaller longest kill spree than her enemy does. On average, she receives less damage than Karthus. This often reflects different amounts of tankyness, but it can also hint that the champ with increased HP has less mobility and thus is unable to flee from additional harm when poked or engaged.
Both League of Legends champs are great champions. Both champs have their strengths, weaknesses, and counters. In League's current meta, Lissandra usually loses when playing against Karthus, with a 47.8% win rate. Therefore, Lissandra makes a bad counter for Karthus.
While Lissandra does have a lower winrate compared to Karthus, when on opposite teams, Lissandra also has a lower level of difficulty that makes her a less challenging champion to learn. You should expect to face a difficult match when picking Lissandra into Karthus.
Additionally, Lissandra also has a good amount of CC and other utility, a similar amount to Karthus. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not a single best champion overall in League of Legends, in Lissandra vs Karthus matchups, Karthus is the better champion with a lower win rate, less champion complexity, and a similar amount of utility to help out your teammates during late stage team fights.
Lissandra is a garbage counter to Karthus. You will do well by focussing your gameplay on maximizing your CS and destroying objectives. If you are able to do that, you should hold your own as Lissandra against Karthus.
To learn all of the intricacies of Lissandra in order to counter Karthus during both the laning and mid / late game phases of League of Legends, you should continue reading to gather a few extra tips and tricks for this matchup. If you pay attention to the build and stats shown here, you will grow your win rate significantly and be closer to League of Legends pro players.
Lissandra usually racks up more CS compared to Karthus. Champs who on average don't get much CS often don't have to have much CS to be effective, such as supports. They are able to scale well off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, usually need several high cost items to be effective. In either case, try to exceed the values reported here to do well.
The most important items to have in your Lissandra versus Karthus build include Malignance, Zhonya's Hourglass, and Shadowflame. When Lissandra included at least these three pieces in her build, she performed much better when fighting Karthus than with many other common item sets. In fact, Lissandra had an average winrate of 47.8% battling Karthus with this build.
To have the highest probability of annihilating Karthus as Lissandra, you should use the Electrocute, Cheap Shot, Eyeball Collection, Ultimate Hunter, Manaflow Band, and Transcendence runes from the Domination and Sorcery rune sets. Of all the rune combinations players used for Lissandra vs Karthus counterpicks, this blending of runes resulted in the best win rate. In fact, these runes provided a 47.8% winrate overall.
By default, tips, statistics, and builds on how to beat Karthus as Lissandra are presented for all ranked divisions. If you would like to narrow the stats and builds to a distinct division, you can use the selection menu at the top of this page.