Take advantage of Flurry by weaving in basic attacks between spell casts - this maximizes damage output and minimizes Energy loss.
Use Sonic Wave before Dragon's Rage so you can chase the target with Resonating Strike.
Self-casting Safeguard and using Iron Will are powerful tools for killing neutral monsters (in the jungle).
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons shown here emphasize several vital K'Sante against Karthus counter statistics that may help us interpret the differences and similarities between the two. K'Sante’s KDA ratio ([kills + assists] / deaths) of NaN is better than Karthus’s ratio of NaN, highlighting that K'Sante may be more central to their team's team fighting effectiveness than Karthus..
K'Sante normally has a slightly smaller longest killing spree than their matchup does. Commonly, they receives more damage than Karthus. This commonly reflects differing health capacities, yet it can also imply that the champion with more HP has less mobility and thus is not able to kite away from further harm when engaged or poked.
Both League champions are great. Both have their strengths, weaknesses, and counters. In League's current meta, K'Sante usually fairs equally well when taking on Karthus, with a 50.6% win rate. Thus, K'Sante makes an ok counter for Karthus.
While K'Sante does have a higher winrate compared to Karthus, when they face off with one another, K'Sante also has a greater difficulty level that makes them a more difficult champion to learn and master. You still need to be cautious when picking K'Sante into Karthusas their relative depth means that you may not be able to reach their full potential without a significant amount of practice beforehand.
Moreover, K'Sante also has some amount of CC and other utility, a similar amount to Karthus. This often makes her just as valuable during team fights, especially when trying to counter champions with a ton of burst damage.
While there is not a single best champion overall in League of Legends, in K'Sante vs Karthus matchups, K'Sante is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your allied champions during late stage team fights.
K'Sante is a decent counter for Karthus. You will do well by focussing your play on increasing your CS and clearing objectives. If you are able to do that, you should hold your own as K'Sante against Karthus.
To truly master K'Sante to counter Karthus during both the lane and mid / late game phases of League of Legends, you should keep reading to gather a few extra tricks and insights into this matchup. If you pay attention to the build and stats shown here, you will increase your win rate significantly and be closer to League of Legends pro players.
K'Sante usually accumulates more CS relative to Karthus. Champions who typically don't earn much CS usualy don't need much CS to be effective, such as supports. They are capable of scaling well off of their abilities and first items alone. Yet, champions with a lot of CS, such as hyper-carries, often need several high cost items to be effective. In either case, try to surpass the numbers displayed on this page to do well.
The ideal items to focus on in your K'Sante versus Karthus build include Sunfire Aegis, Thornmail, and Jak'Sho, The Protean. When K'Sante used at least these three items in their build, they did much better vs. Karthus than with most other commonly used builds. In fact, K'Sante boasted an average win rate of 50.6% when playing against Karthus with these items in their kit.
To have the greatest likelihood of defeating Karthus as K'Sante, you should use the Grasp of the Undying, Demolish, Conditioning, Overgrowth, Approach Velocity, and Biscuit Delivery runes from the Resolve and Inspiration rune sets. Out of all the runes players picked for K'Sante vs Karthus fights, this blending of runes resulted in the best win rate. Moreover, these runes averaged a 50.6% winrate overall.
If you would like to view K'Sante x Karthus tips and counter stats for a a distinct player tier, please choose one from the selection menu above. By default, the stats and guides given are calculated using all games run with these champs.